PXD009944

PXD009944 is an original dataset announced via ProteomeXchange.

Title	Polypropylene mesh implantation for hernia repair triggers myeloid cell-dependent persistent inflammatory foreign body reaction
Description	Polypropylene meshes that are commonly used for surgical groin hernia repair may trigger granulomatous foreign body reactions. Here, we show that asymptomatic patients display mesh-associated inflammatory granulomas long after surgery, which are dominated by monocyte-derived macrophages. In mice, subdermal mesh implantation induces a rapid and strong myeloid cell accumulation, without substantial attenuation for up to 90 days. Myeloid cells segregate into distinct macrophage subsets with separate spatial distribution, activation profiles and functional properties. Protein mass spectrometry confirms the inflammatory nature of the foreign body reaction, as characterized by cytokines, complement activation and immunoglobulin deposition.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:06:18.229.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christian Preisinger
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-05-29 00:05:39	ID requested
1	2019-01-25 00:23:39	announced
2	2019-01-29 07:07:00	announced	Updated publication reference for PubMed record(s): 30674727.
⏵ 3	2024-10-22 04:06:26	announced	2024-10-22: Updated project metadata.

10.1172/jci.insight.123862;

Heymann F, von Trotha KT, Preisinger C, Lynen-Jansen P, Roeth AA, Geiger M, Geisler LJ, Frank AK, Conze J, Luedde T, Trautwein C, Binneb, ö, sel M, Neumann UP, Tacke F, Polypropylene mesh implantation for hernia repair causes myeloid cell-driven persistent inflammation. JCI Insight, 4(2):(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: mouse, inflammation, chemokine, granuloma, macrophages, monocytes, biomaterial

Frank Tacke
contact affiliation	Dept. of Medicine III, University Hospital Aachen, Aachen, Germany
contact email	frank.tacke@gmx.net
lab head
Christian Preisinger
contact affiliation	Proteomics Facility, IZKF Aachen, University Clinic RWTH Aachen
contact email	cpreisinger@ukaachen.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/01/PXD009944

PRIDE project URI

• PRIDE
  1. PXD009944
     1. Label: PRIDE project
     2. Name: Polypropylene mesh implantation for hernia repair triggers myeloid cell-dependent persistent inflammatory foreign body reaction