PXD009900 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells |
Description | TiO2-enriched and non-enriched samples and a pooled TiO2-enriched alkaline phosphatase treated sample from subconfluent A549 lung adenocarcinoma cells line. Cells were subjected to on of the 6 different treatments: Control sample, RNAi mediated depletion of PPP2R1A, CIP2A, or PME-1, and treatment with 100nM Trametinib for 20 hours for control and PPP2R1A depleted cells. Each condition was performed in triplicates with different siRNA sequences. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:06:46.213.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Laxman Yetukuri |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue; monohydroxylated residue; acetylated residue; iodoacetic acid derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-05-25 02:32:50 | ID requested | |
1 | 2018-10-11 09:40:15 | announced | |
⏵ 2 | 2024-10-22 04:06:47 | announced | 2024-10-22: Updated project metadata. |
Publication List
Kauko O, O'Connor CM, Kulesskiy E, Sangodkar J, Aakula A, Izadmehr S, Yetukuri L, Yadav B, Padzik A, Laajala TD, Haapaniemi P, Momeny M, Varila T, Ohlmeyer M, Aittokallio T, Wennerberg K, Narla G, Westermarck J, PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. Sci Transl Med, 10(450):(2018) [pubmed] |
10.1126/scitranslmed.aaq1093; |
Keyword List
curator keyword: Biomedical |
submitter keyword: Phosphoproteomics, PP2A, A549, lung cancer |
Contact List
Jukka Westermarck (lab head) Laxman yetukuri (submitted) |
contact affiliation | Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland |
contact email | jukwes@utu.fi |
lab head | |
Laxman Yetukuri |
contact affiliation | UTU |
contact email | laraye@utu.fi |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD009900
- Label: PRIDE project
- Name: PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells