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PXD009900

PXD009900 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells
DescriptionTiO2-enriched and non-enriched samples and a pooled TiO2-enriched alkaline phosphatase treated sample from subconfluent A549 lung adenocarcinoma cells line. Cells were subjected to on of the 6 different treatments: Control sample, RNAi mediated depletion of PPP2R1A, CIP2A, or PME-1, and treatment with 100nM Trametinib for 20 hours for control and PPP2R1A depleted cells. Each condition was performed in triplicates with different siRNA sequences.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:06:46.213.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLaxman Yetukuri
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue; monohydroxylated residue; acetylated residue; iodoacetic acid derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-05-25 02:32:50ID requested
12018-10-11 09:40:15announced
22024-10-22 04:06:47announced2024-10-22: Updated project metadata.
Publication List
Kauko O, O'Connor CM, Kulesskiy E, Sangodkar J, Aakula A, Izadmehr S, Yetukuri L, Yadav B, Padzik A, Laajala TD, Haapaniemi P, Momeny M, Varila T, Ohlmeyer M, Aittokallio T, Wennerberg K, Narla G, Westermarck J, PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. Sci Transl Med, 10(450):(2018) [pubmed]
10.1126/scitranslmed.aaq1093;
Keyword List
curator keyword: Biomedical
submitter keyword: Phosphoproteomics, PP2A, A549, lung cancer
Contact List
Jukka Westermarck (lab head) Laxman yetukuri (submitted)
contact affiliationTurku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland
contact emailjukwes@utu.fi
lab head
Laxman Yetukuri
contact affiliationUTU
contact emaillaraye@utu.fi
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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