PXD009895

PXD009895 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	METTL13 modulates mRNA translation through methylation of eEF1A at Lys55 and the N-terminus
Description	The experiment aimed at identifying lysine methylation dependent interactions for eEF1A. FLAG-tagged wild type eEF1A and a methylation deficient mutant, carrying lysine-to-arginine mutations of the well-established methylation sites (Lys36, Lys55, Lys79, Lys165 and Lys318) were overexpressed in HEK-293 cells and co-purifying proteins were quantified using the MaxLFQ algorithm. FLAG-tagged
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:12:45.915.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Magnus Jakobsson
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-05-25 01:37:42	ID requested
1	2018-07-04 06:10:10	announced
2	2018-08-28 08:29:04	announced	Updated publication reference for PubMed record(s): 30143613.
⏵ 3	2024-10-22 04:12:49	announced	2024-10-22: Updated project metadata.

Publication List

10.1038/s41467-018-05646-y;
Jakobsson ME, Ma, ł, ecki JM, Halabelian L, Nilges BS, Pinto R, Kudithipudi S, Munk S, Davydova E, Zuhairi FR, Arrowsmith CH, Jeltsch A, Leidel SA, Olsen JV, Falnes P Ø, The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates. Nat Commun, 9(1):3411(2018) [pubmed]

10.1038/s41467-018-05646-y;

Jakobsson ME, Ma, ł, ecki JM, Halabelian L, Nilges BS, Pinto R, Kudithipudi S, Munk S, Davydova E, Zuhairi FR, Arrowsmith CH, Jeltsch A, Leidel SA, Olsen JV, Falnes P Ø, The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates. Nat Commun, 9(1):3411(2018) [pubmed]

Keyword List

curator keyword: Biological
submitter keyword: methylation,eEF1A, interactome

curator keyword: Biological

submitter keyword: methylation,eEF1A, interactome

Contact List

Jesper Velgard Olsen
contact affiliation	Novo Nordisk Foundation Center for Protein Research Proteomics Program Faculty of Health and Medical Sciences University of Copenhagen, Denmark
contact email	jesper.olsen@cpr.ku.dk
lab head
Magnus Jakobsson
contact affiliation	University of Copenhagen
contact email	magnus.jakobsson@cpr.ku.dk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/07/PXD009895
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/07/PXD009895

PRIDE project URI

Repository Record List

[ + ]