PXD009872

PXD009872 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	SET1A-mediated mono-methylation at K342 regulates YAP activation by blocking its nuclear export and promotes tumorigenesis
Description	YAP, a key effector of Hippo pathway, is activated by its translocation from cytoplasm to nucleus to regulate gene expression and promote tumorigenesis. Although the mechanism by which YAP is suppressed in cytoplasm has been well-studied, how the activated YAP is sequestered in the nucleus remains unknown. Here, we demonstrate that YAP is a nucleocytoplasmic shuttling protein and its nuclear export is controlled by SET1A-mediated mono-methylation of YAP at K342, which disrupts the binding of YAP to CRM1. YAP mimetic methylation knockin mice are more susceptible to colorectal tumorigenesis. Clinically, YAP K342 methylation is reversely correlated with cancer survival. Collectively, our study identifies SET1A mediated-mono-methylation at K342 as an essential regulatory mechanism for regulating YAP activity and tumorigenesis.
HostingRepository	MassIVE
AnnounceDate	2018-05-23
AnnouncementXML	Submission_2018-05-23_21:46:06.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	wanda
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Methyl
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-05-23 21:43:10	ID requested
⏵ 1	2018-05-23 21:46:07	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: YAP methylation, SET1A, nuclear export, tumorigenesis

submitter keyword: YAP methylation, SET1A, nuclear export, tumorigenesis

Contact List

Ping Wang
contact affiliation	1Shanghai Tenth People Hospital of Tongji University, School of Medicine and School of Life Science and Technology, Tongji University
contact email	wangp@tongji.edu.cn
lab head
wanda
contact affiliation	ECNU
contact email	782899013@qq.com
dataset submitter

Full Dataset Link List

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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000082393