PXD009870

PXD009870 is an original dataset announced via ProteomeXchange.

Title	Proteomics of JHS samples identifies proteins associated with heart failure
Description	RELEVANCE: Identifying early plasma protein biomarkers that predict the development of heart failure (HF) following myocardial infarction (MI) will help to stratify at risk subjects and provide insight into more effective therapeutic strategies. OBJECTIVE/HYPOTHESIS: The goal of this study was to determine markers of HF in African Americans, using plasma samples collected before the development of symptoms. We propose that early plasma glycoprotein changes will link to later development of heart failure. ApolipoproteinF will be the strongest indicator. METHODS: Plasma samples from a subset of Jackson Heart Study participants with a history of MI but without prevalent heart failure (HF) at visit 2 (2005-2008) were analyzed by glycoproteomics. Individuals were grouped into those who experienced subsequent HF hospitalization after visit 2 (n=15; 3 men/ 12 women) and those without HF hospitalization through 2012 (n=45; 24 men/ 21 women). N-linked plasma glycopeptides were quantified by solid-phase extraction coupled to mass spectrometry and identified using RefSeq and SwissProt. Proteins were mapped for biological processes and functional pathways using Ingenuity Pathway Analysis (IPA) and linked to clinical characteristics.
HostingRepository	PRIDE
AnnounceDate	2018-08-30
AnnouncementXML	Submission_2019-02-11_03:44:26.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Elizabeth Flynn
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetic acid derivatized residue; deamidated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-05-23 08:29:33	ID requested
1	2018-08-30 09:34:26	announced
⏵ 2	2019-02-11 03:44:28	announced	Updated publication reference for PubMed record(s): 30132266, 30729226.

DeLeon-Pennell KY, Mouton AJ, Ero OK, Ma Y, Padmanabhan Iyer R, Flynn ER, Espinoza I, Musani SK, Vasan RS, Hall ME, Fox ER, Lindsey ML, LXR/RXR signaling and neutrophil phenotype following myocardial infarction classify sex differences in remodeling. Basic Res Cardiol, 113(5):40(2018) [pubmed]

Deleon-Pennell KY, Ero OK, Ma Y, Padmanabhan Iyer R, Flynn ER, Espinoza I, Musani SK, Vasan RS, Hall ME, Fox ER, Lindsey ML, Glycoproteomic Profiling Provides Candidate Myocardial Infarction Predictors of Later Progression to Heart Failure. ACS Omega, 4(1):1272-1280(2019) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: myocardial infarction, heart failure, Jackson Heat Study, proteomics

Merry L Lindsey, Ph.D.
contact affiliation	University of Mississippi Medical Center Director, Mississippi Center for Heart Research Professor, Department of Physiology and Biophysics Research Health Scientist, Research Service G.V. (Sonny) Montgomery Veterans Affairs Medical Center
contact email	mllindsey@umc.edu
lab head
Elizabeth Flynn
contact affiliation	University of Mississippi Medical Center
contact email	EFlynn@umc.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD009870
     1. Label: PRIDE project
     2. Name: Proteomics of JHS samples identifies proteins associated with heart failure