PXD009868

PXD009868 is an original dataset announced via ProteomeXchange.

Title	Prostate cancer progression: From non-malignant to bone metastasisProstate cancer progression: From non-malignant to bone metastasis
Description	Proteome characterization of gland confined prostate tumors and non-malignant prostate tissue. Whole cell protein extracts were purified from FFPE radical prostatectomy specimens for a total of 28 tumor samples and 8 adjacent non-malignant prostate tissues. Associated ProteomeXchange identifiers: PXD003430, PXD003452, PXD003515, PXD004132, PXD003615, PXD003636. Quantitative proteomic analysis of adjacent non-malignant prostate tissue (n=8) and gland confined prostate tumors (n=28) obtained from radical prostatectomy procedures; and bone metastatic prostate tumors (n=22) obtained from patients operated to relief spinal cord compression. At the time of surgery, most metastatic patients had relapsed after androgen-deprivation therapy, while 5 were previously untreated.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:13:37.500.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Diego Iglesias-Gato
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-05-23 08:24:02	ID requested
1	2018-08-20 08:48:50	announced
2	2018-08-21 03:35:14	announced	Updated publication reference for PubMed record(s): 30042207.
⏵ 3	2024-10-22 04:13:38	announced	2024-10-22: Updated project metadata.

10.1158/1078-0432.ccr-18-1229;

Iglesias-Gato D, Thysell E, Tyanova S, Crnalic S, Santos A, Lima TS, Geiger T, Cox J, Widmark A, Bergh A, Mann M, Flores-Morales A, Wikstr, ö, m P, The Proteome of Prostate Cancer Bone Metastasis Reveals Heterogeneity with Prognostic Implications. Clin Cancer Res, 24(21):5433-5444(2018) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Prostate cancer bone metastasis

Localized prostate cancer

Prostatectomy

Non-malignant prostate tissue

castration

CRPC

LC-MS/MS

SILAC

quantitative proteomics

Diego Iglesias-Gato
contact affiliation	University of Copenhagen. Department of Drug Design and Pharmacology
contact email	diego.iglesias@sund.ku.dk
lab head
Diego Iglesias-Gato
contact affiliation	University of Copenhagen
contact email	diego.iglesias@sund.ku.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/08/PXD009868

PRIDE project URI

• PRIDE
  1. PXD009868
     1. Label: PRIDE project
     2. Name: Prostate cancer progression: From non-malignant to bone metastasisProstate cancer progression: From non-malignant to bone metastasis