PXD009853

PXD009853 is an original dataset announced via ProteomeXchange.

Title	The responses of the pulmonary pathogen Aspergillus fumigatus to the neutrophil derived oxidant N- chlorotaurine
Description	Aspergillus fumigatus is a pulmonary pathogen to individuals who are immunocompromised (e.g. mylosuppression) and those who display defects in immune equilibrium, commonly observed in the Cystic fibrosis lung and presents itself in the form as allergic bronchopulmonary aspergillosis.32 In the latter disease A. fumigatus airborne conidia penetrate the lower airways, germinate and and grow within in thick tenacious CF mucus. A. fumigatus CF colonized individuals can become sensitized to A. fumigatus secreted allergens and eventually develop a type 2 hypersensitivity reaction to AF allergens, toxins and proteases which are readily replenished into the mucus which can directly cause cell damage and peeling at the bronco – epithelium interface. A. fumigatus also induces invasive disease which carries up to 90% mortality. The effect of neutrophil oxidant NCT on A. fumigatus was determined as neutrophils are the first line of cellular defense against A. fumigatus.
HostingRepository	PRIDE
AnnounceDate	2018-12-19
AnnouncementXML	Submission_2018-12-21_01:28:08.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gerard Sheehan
SpeciesList	scientific name: Aspergillus fumigatus var. fumigatus; NCBI TaxID: 41122;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-05-22 01:41:00	ID requested
1	2018-12-19 07:54:37	announced
⏵ 2	2018-12-21 01:28:10	announced	Updated publication reference for PubMed record(s): 30542078.

Scoma A, Heyer R, Rifai R, Dandyk C, Marshall I, Kerckhof FM, Marietou A, Boshker HTS, Meysman FJR, Malmos KG, Vosegaard T, Vermeir P, Banat IM, Benndorf D, Boon N, Reduced TCA cycle rates at high hydrostatic pressure hinder hydrocarbon degradation and obligate oil degraders in natural, deep-sea microbial communities. ISME J, 13(4):1004-1018(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Aspergillus fumigatus NCT N-chlorotaurine proteomics infection lung Cystic fibrosis ABPA

Prof. Kevin Kavanagh
contact affiliation	Medical Mycology Unit, Department of Biology, Maynooth University, Maynooth, Co. Kildare, Ireland.
contact email	kevin.kavanagh@mu.ie
lab head
Gerard Sheehan
contact affiliation	Maynooth University
contact email	gerard.sheehan.2013@mumail.ie
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/12/PXD009853

PRIDE project URI

• PRIDE
  1. PXD009853
     1. Label: PRIDE project
     2. Name: The responses of the pulmonary pathogen Aspergillus fumigatus to the neutrophil derived oxidant N- chlorotaurine