PXD009843

PXD009843 is an original dataset announced via ProteomeXchange.

Title	Mutation-specific and common phosphotyrosine signatures of KRAS G12D and G13D alleles
Description	KRAS is one of the most frequently mutated genes across all cancer subtypes. Two of the most frequent oncogenic KRAS mutations observed in patients result in glycine to aspartic acid substitution at either codon 12 (G12D) or 13 (G13D). Although the biochemical differences between these two predominant mutations are not fully understood, distinct clinical features of the resulting tumors suggest involvement of disparate signaling mechanisms. When we compared the global and phosphotyrosine proteomic profiles of isogenic colorectal cancer cell lines bearing either G12D or G13D KRAS mutation, we observed both shared as well as unique signaling events induced by the two KRAS mutations.
HostingRepository	PRIDE
AnnounceDate	2021-06-09
AnnouncementXML	Submission_2021-06-09_12:38:23.739.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Akhilesh Pandey
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2018-05-21 01:29:40	ID requested
⏵ 1	2021-06-09 12:38:24	announced

Tahir R, Renuse S, Udainiya S, Madugundu AK, Cutler JA, Nirujogi RS, Na CH, Xu Y, Wu X, Pandey A, G12D and G13D Alleles. J Proteome Res, 20(1):670-683(2021) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: KRAS, SW48, G12D mutation, G13D mutation, signaling, phosphoproteome

Akhilesh Pandey, M.D, Ph.D.
contact affiliation	733 N. Broadway Miller Research Building room 527 Johns Hopkins University Baltimore, MD 21205
contact email	pandey@jhmi.edu
lab head
Akhilesh Pandey
contact affiliation	Johns Hopkins University
contact email	pandey@jhmi.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD009843
     1. Label: PRIDE project
     2. Name: Mutation-specific and common phosphotyrosine signatures of KRAS G12D and G13D alleles