PXD009839

PXD009839 is an original dataset announced via ProteomeXchange.

Title	Orchestrating protein acetylation: a toggle for cellular defense versus virus replication
Description	Emerging evidence points to protein acetylation as a nexus at the interface of virus-host interactions. However, global protein acetylation is understudied during infection, and the temporal control and function of acetylation in the context of infection remains poorly understood. Here, we present the first temporal-spatial characterization of acetylation during infection with human cytomegalovirus (HCMV). By using acetyl-peptide immunoaffinity purification, we identified dynamic changes in acetylation events on both cellular and viral proteins over the course of HCMV infection. Our subsequent analyses demonstrated that these acetylations functionally contribute to the progression of infection.
HostingRepository	PRIDE
AnnounceDate	2018-11-21
AnnouncementXML	Submission_2018-11-21_05:13:22.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Laura Murray
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-05-18 09:37:53	ID requested
⏵ 1	2018-11-21 05:13:23	announced

Dataset with its publication pending

submitter keyword: proteomics, cytomegalovirus, HCMV, viral infection, acetylation, acetylome, acetyl-IP

Ileana Cristea
contact affiliation	Princeton University
contact email	icristea@princeton.edu
lab head
Laura Murray
contact affiliation	Princeton University
contact email	lamurray@princeton.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/11/PXD009839

PRIDE project URI

• PRIDE
  1. PXD009839
     1. Label: PRIDE project
     2. Name: Orchestrating protein acetylation: a toggle for cellular defense versus virus replication