PXD009833

PXD009833 is an original dataset announced via ProteomeXchange.

Title	Mitochondrial Network Organization during Neuronal Reprogramming, MT_DF_SEC
Description	The study focuses on an extensive biochemical fractionation with in-depth quantitative mass spectrometric profiling in the mitochondrial (mt) extracts of cultured human NTera2 embryonal carcinoma stem cells (i.e. ECSCs or undifferentiated state) and upon exposure to retinoic acid-induced differentiated neurons (DNs) to establish a network of high-quality mt protein-protein interactions. The resulting network showed that most of the native mt protein complexes with predicted subunits are previously unreported and endured extensive changes during neuronal differentiation and influence neuronal function and neurodegenerative disorder attributes.
HostingRepository	PRIDE
AnnounceDate	2020-01-09
AnnouncementXML	Submission_2020-01-09_08:40:49.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sadhna Phanse
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2018-05-18 05:45:54	ID requested
⏵ 1	2020-01-09 08:40:51	announced

Moutaoufik MT, Malty R, Amin S, Zhang Q, Phanse S, Gagarinova A, Zilocchi M, Hoell L, Minic Z, Gagarinova M, Aoki H, Stockwell J, Jessulat M, Goebels F, Broderick K, Scott NE, Vlasblom J, Musso G, Prasad B, Lamantea E, Garavaglia B, Rajput A, Murayama K, Okazaki Y, Foster LJ, Bader GD, Cayabyab FS, Babu M, Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. iScience, 19():1114-1132(2019) [pubmed]

curator keyword: Biological

submitter keyword: Biochemical fractionation

CI and CIV deficiencies

Differentiated neuronal cells

Human NTera2 embryonal carcinoma stem cells

Mass Spectrometry

Mitochondrial proteins

Mitochondrial interaction landscape

Proteomics

Protein complexes

Patient fibroblasts

Neurodegeneration

Orphans

Mohan Babu
contact affiliation	Associate Professor Department of Biochemistry Room 220, Research and Innovation Centre, University of Regina, Regina, Saskatchewan S4S 0A2
contact email	mohan.babu@uregina.ca
lab head
Sadhna Phanse
contact affiliation	University of Toronto; University of Regina
contact email	srphanse@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/01/PXD009833

PRIDE project URI

• PRIDE
  1. PXD009833
     1. Label: PRIDE project
     2. Name: Mitochondrial Network Organization during Neuronal Reprogramming, MT_DF_SEC