PXD009778

PXD009778 is an original dataset announced via ProteomeXchange.

Title	Global Succinylome Analysis in Aeromonas hydrophila ATCC 7966
Description	The succinylated modification on bacterial protein lysine residues is currently reported to be crucial for regulating cellular physiology and pathology. In this study, to investigate the effect of the lysine succinylation modification on the biological regulation in a well-known fish pathogen, Aeromonas hydrophila, a highly affinity purification was performed to enrich lysine succinylation peptides in A. hydrophila and then identified a total 2174 lysine succinylation sites on 666 proteins with LC-MS/MS. The further motif analysis showed eight motifs surrounding the central lysine succinylated residue were conservative which share some common preferences with other bacterial species. Gene ontology analysis showed that these succinylated proteins involved in diverse metabolic pathways and biological processes, such as translation, protein export and central metabolic pathways. In general, our study provides a significant insight into the functions of lysine succinylation in the cellular physiology and pathology in A.hydrophila.
HostingRepository	iProX
AnnounceDate	2018-10-17
AnnouncementXML	Submission_2018-10-17_00:03:38.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiangmin Lin
SpeciesList	scientific name: Aeromonas hydrophila subsp. hydrophila ATCC 7966; NCBI TaxID: 380703;
ModificationList	N6-succinyl-L-lysine
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-05-14 19:44:04	ID requested
1	2018-05-14 19:44:19	announced
⏵ 2	2018-10-17 00:03:38	announced	Upload new files.

Dataset with its publication pending

submitter keyword: Succinylome

immunoaffinity enrichment

Aeromonas hydrophila

Xiangmin Lin
contact affiliation	Fujian Agricultural and Forestry University
contact email	xiangmin@fafu.edu.cn
lab head
Xiangmin Lin
contact affiliation	Fujian Agricultural and Forestry University
contact email	xiangmin@fafu.edu.cn
dataset submitter

iProX dataset URI