PXD009711

PXD009711 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Mode of action studies for a novel anti-leishmania compound
Description	We describe the development of a novel anti-leishmanial drug-like chemical series based on a pyrazolopyrimidine scaffold. The leading compound is efficacious in a mouse model of visceral leishmaniasis, and has suitable physicochemical, pharmacokinetic and toxicological properties for further development and has been declared a preclinical candidate. Detailed mode of action studies indicate that compounds from this series act principally by inhibiting the parasite protein kinases.
HostingRepository	PRIDE
AnnounceDate	2018-11-30
AnnouncementXML	Submission_2018-11-30_06:21:40.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michael Urbaniak
SpeciesList	scientific name: Leishmania donovani; NCBI TaxID: 5661;
ModificationList	carbamoylated residue; monohydroxylated residue; acetylated residue
Instrument	LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-05-08 05:31:10	ID requested
⏵ 1	2018-11-30 06:21:41	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

curator keyword: Biomedical
submitter keyword: Chemical proteomics, Leishmania

curator keyword: Biomedical

submitter keyword: Chemical proteomics, Leishmania

Contact List

Ian H Gilbert
contact affiliation	Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom
contact email	i.h.gilbert@dundee.ac.uk
lab head
Michael Urbaniak
contact affiliation	Lancaster University
contact email	m.urbaniak@lancaster.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/11/PXD009711
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/11/PXD009711

PRIDE project URI

Repository Record List

[ + ]