PXD009711 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mode of action studies for a novel anti-leishmania compound |
Description | We describe the development of a novel anti-leishmanial drug-like chemical series based on a pyrazolopyrimidine scaffold. The leading compound is efficacious in a mouse model of visceral leishmaniasis, and has suitable physicochemical, pharmacokinetic and toxicological properties for further development and has been declared a preclinical candidate. Detailed mode of action studies indicate that compounds from this series act principally by inhibiting the parasite protein kinases. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:44:52.195.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Michael Urbaniak |
SpeciesList | scientific name: Leishmania donovani; NCBI TaxID: 5661; |
ModificationList | carbamoylated residue; monohydroxylated residue; acetylated residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-05-08 05:31:10 | ID requested | |
1 | 2018-11-30 06:21:41 | announced | |
⏵ 2 | 2024-10-22 04:44:52 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biomedical |
submitter keyword: Leishmania,Chemical proteomics |
Contact List
Ian H Gilbert |
contact affiliation | Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom |
contact email | i.h.gilbert@dundee.ac.uk |
lab head | |
Michael Urbaniak |
contact affiliation | Lancaster University |
contact email | m.urbaniak@lancaster.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/11/PXD009711 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD009711
- Label: PRIDE project
- Name: Mode of action studies for a novel anti-leishmania compound