PXD009704

PXD009704 is an original dataset announced via ProteomeXchange.

Title	IIS-mediated modulation of DIGs proteome in C. elegans.
Description	Reducing insulin/IGF-1 signaling (IIS) extends lifespan, promotes protein homeostasis (proteostasis) and elevates stress resistance of worms, flies and mammals. How these functions are orchestrated across the organism is only partially understood. One prominent group of IIS-regulated encode for lipid metabolizing enzymes. Thus, we asked whether IIS reduction modulates the protein content and functionality of membranal lipid assemblies. We discovered that in the nematode Caenorhabditis elegans, the IIS positively regulates the expression of caveolin-1 (cav-1), a gene which is primarily expressed in neurons of the adult worm and underlies the formation of caveolae, a subtype of lipid microdomains that serve as platforms for signaling complexes. Accordingly, IIS reduction lowers cav-1 expression and lessens the quantity of neuronal caveolae. Reduced cav-1 expression extends lifespan and mitigates toxic protein aggregation by modulating the expression of aging-regulating and signaling-promoting genes. Our findings define caveolae as aging-governing signaling centers and underscore the potential for cav-1 as a novel therapeutic target for the promotion of healthy aging.
HostingRepository	PRIDE
AnnounceDate	2018-05-09
AnnouncementXML	Submission_2018-08-27_07:38:21.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ehud Cohen
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap XL

Revision	Datetime	Status	ChangeLog Entry
0	2018-05-07 06:37:15	ID requested
1	2018-05-09 00:14:02	announced
⏵ 2	2018-08-27 07:38:22	announced	Updated publication reference for PubMed record(s): 29945933.

Roitenberg N, Bejerano-Sagie M, Boocholez H, Moll L, Marques FC, Golodetzki L, Nevo Y, Elami T, Cohen E, . EMBO Rep, 19(8):(2018) [pubmed]

curator keyword: Biological

submitter keyword: Aging, Insulin/IGF signaling, C. elegans, Detergent Resistant Granules.

Ehud Cohen
contact affiliation	Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada (IMRIC). School of Medicine. The Hebrew University of Jerusalem, Israel.
contact email	ehudc@ekmd.huji.ac.il
lab head
Ehud Cohen
contact affiliation	The Hebrew University of Jerusalem. The Institute for Medical Research Israel-Canada (IMRIC), School of Medicine.
contact email	robertr@ekmd.huji.ac.il
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/05/PXD009704

PRIDE project URI

• PRIDE
  1. PXD009704
     1. Label: PRIDE project
     2. Name: IIS-mediated modulation of DIGs proteome in C. elegans.