PXD009635 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | proteomics identification of total cellular proteins after five types of nanocarbon incubations with macrophages |
Description | Single-walled-carbon-nanohorns (SNH) exhibit huge application prospects. Notably, spherical SNH possess different morphology from conventional carbon nanotubes (CNT). However, there is a tremendous lack of studies on the nanotoxicity and mechanism of SNH, and their comparison with nanotubes. Here, the dissimilarity between SNH and CNT is found in nano-protein interaction. To validate the potential protein-mediated membrane disturbance caused by different nanocarbons, LC-MS/MS based on LFQ proteomics technology is utilized to compare the differences of total cellular proteins after different nanocarbon incubations and evaluate the impact of nanocarbons on protein expressions. |
HostingRepository | PRIDE |
AnnounceDate | 2018-06-25 |
AnnouncementXML | Submission_2018-06-25_05:53:19.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Bing He |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-05-01 01:50:37 | ID requested | |
⏵ 1 | 2018-06-25 05:53:21 | announced | |
Publication List
He B, Shi Y, Liang Y, Yang A, Fan Z, Yuan L, Zou X, Chang X, Zhang H, Wang X, Dai W, Wang Y, Zhang Q, Single-walled carbon-nanohorns improve biocompatibility over nanotubes by triggering less protein-initiated pyroptosis and apoptosis in macrophages. Nat Commun, 9(1):2393(2018) [pubmed] |
Keyword List
curator keyword: Technical |
submitter keyword: single-walled-carbon-nanohorns, nanotubes, proteomics, LC-MS/MS, nano-protein interaction |
Contact List
Bing He |
contact affiliation | 1.Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China 2.State Key Laboratory of Natural and Biomimetic Drugs, Beijing 100191, China Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China |
contact email | hebingmumu@163.com |
lab head | |
Bing He |
contact affiliation | School of Pharmaceutical Sciences; State Key Laboratory of Natural and Biomimetic Drugs; Peking University; China |
contact email | hebingmumu@163.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/06/PXD009635 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD009635
- Label: PRIDE project
- Name: proteomics identification of total cellular proteins after five types of nanocarbon incubations with macrophages