PXD009628

PXD009628 is an original dataset announced via ProteomeXchange.

Title	Improved biocompatibility of single-walled-carbon-nanohorns over nanotubes by triggering less protein-initiated pyroptosis and apoptosis in macrophages (proteomics identification of total cellular proteins based on identical intracellular nanocarbons)
Description	Single-walled-carbon-nanohorns (SNH) exhibit huge application prospects. Notably, spherical SNH possess different morphology from conventional carbon nanotubes (CNT). However, there is a tremendous lack of studies on the nanotoxicity and mechanism of SNH, and their comparison with nanotubes. Here, the dissimilarity between SNH and CNT is found in nano-protein interaction. To validate the potential protein-mediated membrane disturbance caused by different nanocarbons, LC-MS/MS based on LFQ proteomics technology is utilized to compare the differences of total cellular proteins after different nanocarbon incubations and evaluate the impact of nanocarbons on protein expressions.The incubation concentrations of nanocarbons were normalized to assure the identical intracellular amount of nanomaterials.
HostingRepository	PRIDE
AnnounceDate	2018-06-25
AnnouncementXML	Submission_2018-06-25_05:43:01.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bing He
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-04-30 01:50:20	ID requested
⏵ 1	2018-06-25 05:43:02	announced

He B, Shi Y, Liang Y, Yang A, Fan Z, Yuan L, Zou X, Chang X, Zhang H, Wang X, Dai W, Wang Y, Zhang Q, Single-walled carbon-nanohorns improve biocompatibility over nanotubes by triggering less protein-initiated pyroptosis and apoptosis in macrophages. Nat Commun, 9(1):2393(2018) [pubmed]

curator keyword: Technical

submitter keyword: single-walled-carbon-nanohorns, nanosafety, pyroptosis, apoptosis, GPNMB, nanotubes, proteomics

Bing He
contact affiliation	1.Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China 2.State Key Laboratory of Natural and Biomimetic Drugs, Beijing 100191, China 3.Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
contact email	hebingmumu@163.com
lab head
Bing He
contact affiliation	School of Pharmaceutical Sciences; State Key Laboratory of Natural and Biomimetic Drugs; Peking University; China
contact email	hebingmumu@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/06/PXD009628

PRIDE project URI

• PRIDE
  1. PXD009628
     1. Label: PRIDE project
     2. Name: Improved biocompatibility of single-walled-carbon-nanohorns over nanotubes by triggering less protein-initiated pyroptosis and apoptosis in macrophages (proteomics identification of total cellular proteins based on identical intracellular nanocarbons)