PXD009589

PXD009589 is an original dataset announced via ProteomeXchange.

Title	Proteomes of paired human cerebrospinal fluid and plasma
Description	Shotgun proteomics using liquid chromatography tandem mass spectrometry (LC MS/MS) can characterize in-depth human cerebrospinal fluid (CSF) and plasma proteomes. Nonetheless, association between the proteomes in each compartment has not been described to the full extent using such technology due to sample size limitations. We deployed MS-based proteomics in paired CSF and plasma samples volunteered by 120 elders with (n = 72) and without cognitive impairment (n = 48) to comprehensively examine the compartmental differences and the influence of blood-brain barrier (BBB) integrity. We further tested the hypothesis that BBB breakdown can be identified from CSF and plasma proteome alterations in non-demented elders.
HostingRepository	PRIDE
AnnounceDate	2019-02-15
AnnouncementXML	Submission_2019-02-15_06:31:34.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Loïc Dayon
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2018-04-24 06:20:07	ID requested
⏵ 1	2019-02-15 06:31:35	announced

Dayon L, Cominetti O, Wojcik J, Galindo AN, Oikonomidi A, Henry H, Migliavacca E, Kussmann M, Bowman GL, Popp J, Proteomes of Paired Human Cerebrospinal Fluid and Plasma: Relation to Blood-Brain Barrier Permeability in Older Adults. J Proteome Res, 18(3):1162-1174(2019) [pubmed]

curator keyword: Biological

submitter keyword: Human, plasma, CSF, LC-MS/MS, shotgun, Alzheimer, blood-brain barrier, clinical proteomics

Loïc Dayon
contact affiliation	Proteomics Team, Nestlé Institute of Health Sciences, Lausanne, Switzerland
contact email	loic.dayon@rd.nestle.com
lab head
Loïc Dayon
contact affiliation	Nestlé Institute of Health Sciences SA
contact email	loic.dayon@rd.nestle.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/02/PXD009589

PRIDE project URI

• PRIDE
  1. PXD009589
     1. Label: PRIDE project
     2. Name: Proteomes of paired human cerebrospinal fluid and plasma