PXD009577

PXD009577 is an original dataset announced via ProteomeXchange.

Title	Getting to the heart of the matter: Multispecies heart tissue proteome characterization
Description	Structural birth defects are the leading cause of infant mortality in the US and Europe. Among these, congenital heart disease (CHD) is the most common. Historically, Xenopus, mouse, and pig have provided models for CHD. However, it remains unknown what proteins and pathways are conserved between these species and human. Furthermore, the proteome driving the differences between three-chambered (Xenopus) and four-chambered (mammalian) hearts is unknown. Comparative proteomics of heart tissue from species at different evolutionary points can reveal molecular processes underlying heart function. We examined heart tissue proteomes of Xenopus tropicalis, Xenopus laevis, Mus musculus, and Sus scrofa and assessed protein expression changes in the context of pathways and protein complexes, and enrichment of corresponding genes in human heart diseases.
HostingRepository	PRIDE
AnnounceDate	2019-08-01
AnnouncementXML	Submission_2019-08-01_04:35:25.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Joel Federspiel
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Xenopus laevis (African clawed frog); NCBI TaxID: 8355; scientific name: Xenopus tropicalis; NCBI TaxID: 8364; scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-04-23 07:17:38	ID requested
⏵ 1	2019-08-01 04:35:26	announced

Dataset with its publication pending

curator keyword: Biological

submitter keyword: Heart tissue, label-free quant, multispecies, heart proteome

Ileana M Cristea
contact affiliation	Department of Molecular Biology, Princeton University, United States
contact email	icristea@Princeton.EDU
lab head
Joel Federspiel
contact affiliation	Princeton University
contact email	joel.federspiel@princeton.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/08/PXD009577

PRIDE project URI

• PRIDE
  1. PXD009577
     1. Label: PRIDE project
     2. Name: Getting to the heart of the matter: Multispecies heart tissue proteome characterization