PXD009568

PXD009568 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Lgl protein interactome
Description	To identify Lgl binding proteins, we purified Lgl-containing protein complexes from cultured Drosophila S2 cells, using the single-step streptavidin purification from stable cell lines expressing SBP-tagged Lgl, followed by nanoLC-MS/MS analysis of the interactors. This study revealed the binding of Lgl to Vap33, which we further connected to the function of the vacuolar ATPase and regulation of Notch signaling.
HostingRepository	PRIDE
AnnounceDate	2018-06-10
AnnouncementXML	Submission_2018-06-10_08:40:09.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alexey Veraksa
SpeciesList	scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-04-23 02:00:08	ID requested
⏵ 1	2018-06-10 08:40:11	announced

Publication List

Portela M, Yang L, Paul S, Li X, Veraksa A, Parsons LM, Richardson HE, Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex. Sci Signal, 11(533):(2018) [pubmed]

Portela M, Yang L, Paul S, Li X, Veraksa A, Parsons LM, Richardson HE, Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex. Sci Signal, 11(533):(2018) [pubmed]

Keyword List

curator keyword: Biological
submitter keyword: Lgl, Drosophila, S2 cells

curator keyword: Biological

submitter keyword: Lgl, Drosophila, S2 cells

Contact List

Alexey Veraksa
contact affiliation	Biology Department, University of Massachusetts Boston, USA
contact email	alexey.veraksa@umb.edu
lab head
Alexey Veraksa
contact affiliation	University of Massachusetts Boston
contact email	alexey.veraksa@umb.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/06/PXD009568
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/06/PXD009568

PRIDE project URI

Repository Record List

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