PXD009558

PXD009558 is an original dataset announced via ProteomeXchange.

Title	Thioredoxin reduces complement factor H and alters its complement regulatory function
Description	Complement factor H (CFH) is an enzyme responsible for inactivating components of the complement cascade, thus limiting the downstream effector mechanisms which would otherwise occur were the process to continue unregulated. In view of the close structural and functional homology between β2GPI and CFH we sought in this study to determine whether CFH is a substrate for oxidoreductases, and whether distinct redox forms can be found in the plasma or serum of individuals and if so to determine the functional implications of such redox transformations to CFH complement regulatory function. This dataset relates to the detection of reduced disulfide bonds in CFH by TRX-1/TRX-R/NADPH.
HostingRepository	PRIDE
AnnounceDate	2019-05-20
AnnouncementXML	Submission_2019-05-20_00:21:23.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jason Wong
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2018-04-20 06:02:32	ID requested
⏵ 1	2019-05-20 00:21:24	announced

Krilis M, Qi M, Qi J, Wong JWH, Guymer R, Liew G, Hunyor AP, Madigan M, McCluskey P, Weaver J, Krilis SA, Giannakopoulos B, Dual roles of different redox forms of complement factor H in protecting against age related macular degeneration. Free Radic Biol Med, 129():237-246(2018) [pubmed]

curator keyword: Biological

submitter keyword: Complement factor H, Thioredoxin, Disulfide Bonds

Steven Krilis
contact affiliation	Faculty of Medicine, St George and Sutherland Clinical School, University of New South Wales, St George Hospital, Sydney, New South Wales, Australia
contact email	s.krilis@unsw.edu.au
lab head
Jason Wong
contact affiliation	Medicine
contact email	jason.wong@unsw.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/05/PXD009558

PRIDE project URI

• PRIDE
  1. PXD009558
     1. Label: PRIDE project
     2. Name: Thioredoxin reduces complement factor H and alters its complement regulatory function