PXD009558 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Thioredoxin reduces complement factor H and alters its complement regulatory function |
Description | Complement factor H (CFH) is an enzyme responsible for inactivating components of the complement cascade, thus limiting the downstream effector mechanisms which would otherwise occur were the process to continue unregulated. In view of the close structural and functional homology between β2GPI and CFH we sought in this study to determine whether CFH is a substrate for oxidoreductases, and whether distinct redox forms can be found in the plasma or serum of individuals and if so to determine the functional implications of such redox transformations to CFH complement regulatory function. This dataset relates to the detection of reduced disulfide bonds in CFH by TRX-1/TRX-R/NADPH. |
HostingRepository | PRIDE |
AnnounceDate | 2019-05-20 |
AnnouncementXML | Submission_2019-05-20_00:21:23.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jason Wong |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-04-20 06:02:32 | ID requested | |
⏵ 1 | 2019-05-20 00:21:24 | announced | |
Publication List
Krilis M, Qi M, Qi J, Wong JWH, Guymer R, Liew G, Hunyor AP, Madigan M, McCluskey P, Weaver J, Krilis SA, Giannakopoulos B, Dual roles of different redox forms of complement factor H in protecting against age related macular degeneration. Free Radic Biol Med, 129():237-246(2018) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: Complement factor H, Thioredoxin, Disulfide Bonds |
Contact List
Steven Krilis |
contact affiliation | Faculty of Medicine, St George and Sutherland Clinical School, University of New South Wales, St George Hospital, Sydney, New South Wales, Australia |
contact email | s.krilis@unsw.edu.au |
lab head | |
Jason Wong |
contact affiliation | Medicine |
contact email | jason.wong@unsw.edu.au |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD009558
- Label: PRIDE project
- Name: Thioredoxin reduces complement factor H and alters its complement regulatory function