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PXD009558

PXD009558 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThioredoxin reduces complement factor H and alters its complement regulatory function
DescriptionComplement factor H (CFH) is an enzyme responsible for inactivating components of the complement cascade, thus limiting the downstream effector mechanisms which would otherwise occur were the process to continue unregulated. In view of the close structural and functional homology between β2GPI and CFH we sought in this study to determine whether CFH is a substrate for oxidoreductases, and whether distinct redox forms can be found in the plasma or serum of individuals and if so to determine the functional implications of such redox transformations to CFH complement regulatory function. This dataset relates to the detection of reduced disulfide bonds in CFH by TRX-1/TRX-R/NADPH.
HostingRepositoryPRIDE
AnnounceDate2019-05-20
AnnouncementXMLSubmission_2019-05-20_00:21:23.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJason Wong
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentLTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-04-20 06:02:32ID requested
12019-05-20 00:21:24announced
Publication List
Krilis M, Qi M, Qi J, Wong JWH, Guymer R, Liew G, Hunyor AP, Madigan M, McCluskey P, Weaver J, Krilis SA, Giannakopoulos B, Dual roles of different redox forms of complement factor H in protecting against age related macular degeneration. Free Radic Biol Med, 129():237-246(2018) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: Complement factor H, Thioredoxin, Disulfide Bonds
Contact List
Steven Krilis
contact affiliationFaculty of Medicine, St George and Sutherland Clinical School, University of New South Wales, St George Hospital, Sydney, New South Wales, Australia
contact emails.krilis@unsw.edu.au
lab head
Jason Wong
contact affiliationMedicine
contact emailjason.wong@unsw.edu.au
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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