PXD009531

PXD009531 is an original dataset announced via ProteomeXchange.

Title	Unveiling the Peptide Motifs of HLA-C and HLA-G from Naturally Presented Peptides and Generation of Binding Prediction Matrices
Description	The classical HLA-C and the nonclassical HLA-E and HLA-G molecules play important roles both in the innate and adaptive immune system. Starting already during embryogenesis and continuing throughout our lives, these three Ags exert major functions in immune tolerance, defense against infections, and anticancer immune responses. Despite these important roles, identification and characterization of the peptides presented by these molecules has been lacking behind the more abundant HLA-A and HLA-B gene products. In this study, we elucidated the peptide specificities of these HLA molecules using a comprehensive analysis of naturally presented peptides.
HostingRepository	PRIDE
AnnounceDate	2018-04-20
AnnouncementXML	Submission_2018-04-20_05:42:25.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michael Ghosh
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2018-04-18 07:21:51	ID requested
⏵ 1	2018-04-20 05:42:26	announced

Di Marco M, Schuster H, Backert L, Ghosh M, Rammensee HG, Stevanovi, ć S, Unveiling the Peptide Motifs of HLA-C and HLA-G from Naturally Presented Peptides and Generation of Binding Prediction Matrices. J Immunol, 199(8):2639-2651(2017) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: LC-MSMS, HLA-C, HLA-G, HLA-E, Binding Prediction

Peptide Motifs

Stefan Stevanovic
contact affiliation	Department of Immunology, Interfaculty Institute for Cell Biology, Tübingen, Germany
contact email	stefan.stevanovic@uni-tuebingen.de
lab head
Michael Ghosh
contact affiliation	Department of Immunology, Tübingen
contact email	Michaelghosh@gmx.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/04/PXD009531

PRIDE project URI

• PRIDE
  1. PXD009531
     1. Label: PRIDE project
     2. Name: Unveiling the Peptide Motifs of HLA-C and HLA-G from Naturally Presented Peptides and Generation of Binding Prediction Matrices