PXD009526

PXD009526 is an original dataset announced via ProteomeXchange.

Title	Conformational control and DNA binding mechanism of the metazoan origin recognition complex
Description	Chemical cross-linking coupled to mass spectrometry was used to study the architecture and conformational state(s) of the Drosophila melanogaster origin replication complex (ORC). Two versions of the ORC were subjected to cross-linking with the amine-reactive reagents, disuccinimidyl suberate (DSS). One was a complex with truncated subunits (“core complex”), one with full-length sequences of all six subunits (“full-length complex”).
HostingRepository	PRIDE
AnnounceDate	2018-06-11
AnnouncementXML	Submission_2018-06-18_03:31:27.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alexander Leitner
SpeciesList	scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2018-04-17 08:40:32	ID requested
1	2018-06-11 07:43:01	announced
⏵ 2	2018-06-18 03:31:28	announced	Updated publication reference for PubMed record(s): 29899147.

Bleichert F, Leitner A, Aebersold R, Botchan MR, Berger JM, Conformational control and DNA-binding mechanism of the metazoan origin recognition complex. Proc Natl Acad Sci U S A, 115(26):E5906-E5915(2018) [pubmed]

curator keyword: Biological

submitter keyword: Chemical cross-linking

DSS

structural proteomics

origin recognition complex, autoinhibition

Alexander Leitner
contact affiliation	ETH Zurich, Institute of Molecular Systems Biology
contact email	leitner@imsb.biol.ethz.ch
lab head
Alexander Leitner
contact affiliation	ETH Zurich, Institute of Molecular Systems Biology
contact email	leitner@imsb.biol.ethz.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/06/PXD009526

PRIDE project URI

• PRIDE
  1. PXD009526
     1. Label: PRIDE project
     2. Name: Conformational control and DNA binding mechanism of the metazoan origin recognition complex