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DataSet Summary

  • HostingRepository: PRIDE
  • AnnounceDate: 2018-06-13
  • AnnouncementXML: Submission_2018-06-13_03:47:32.xml
  • DigitalObjectIdentifier:
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original data
  • RepositorySupport: Unsupported dataset by repository
  • PrimarySubmitter: Edit Szodorai
  • Title: Interactome of Ca2+-bound secretagogin in mouse embryonic (E13.5) pancreas
  • Description: By using His6-tagged recombinant human secretagogin in the presence of Ca2+ (100 µM), we isolated its putative interacting partners from mouse embryonic (E13.5) pancreata and identified their amino acid sequences by mass spectrometry. Next to previously described interacting partners (participating in vesicle-mediated transport, cytoskeletal organization and members of chaperonin-containing complex), we found a substantial group of proteins involved in proteasomal catabolic process including 15 different subunits of the 26S proteasome. Our data support that secretagogin protects Pdx1 from proteasomal degradation to control a transcriptional program required for β cell specification.
  • SpeciesList: scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
  • ModificationList: monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
  • Instrument: Q Exactive

Dataset History

VersionDatetimeStatusChangeLog Entry
02018-04-16 04:09:04ID requested
12018-06-13 03:47:32announced

Publication List

  1. Dataset with its publication pending

Keyword List

  1. curator keyword: Biological
  2. submitter keyword: His6-tagged recombinant secretagogin, pull down, mouse embryonic (E13.5) pancreas, protein-protein interactions

Contact List

    Univ. Prof. Dr. Tibor Harkany
    • contact affiliation: 1 Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090 Vienna, Austria; 2 Department of Neuroscience, Karolinska Institutet, Retzius väg 8, SE-17177 Stockholm, Sweden
    • contact email: tibor.harkany@meduniwien.ac.at
    • lab head:
    Edit Szodorai
    • contact affiliation: Dept. of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria
    • contact email: edit.szodorai@meduniwien.ac.at
    • dataset submitter:

Full Dataset Link List

  1. Dataset FTP location
  2. PRIDE project URI
Repository Record List
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