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DataSet Summary

  • HostingRepository: PRIDE
  • AnnounceDate: 2018-06-13
  • AnnouncementXML: Submission_2018-06-20_00:20:16.xml
  • DigitalObjectIdentifier:
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original data
  • RepositorySupport: Unsupported dataset by repository
  • PrimarySubmitter: Martin Kollmar
  • Title: Yeast genetic codes
  • Description: While the “universal” genetic code is now known not to be universal, and stop codons can have multiple meanings, one regularity remains, namely that for a given sense codon there is a unique translation. Examining CUG usage in yeasts that have transferred CUG away from leucine, we here report the first example of dual coding: Ascoidea asiatica stochastically encodes CUG as both serine and leucine. This is deleterious as evidenced by CUG codons being rare, never at conserved serine/leucine residues and predominantly in lowly expressed genes. Related yeasts solve the problem by loss-of-function of one of the two tRNAs. This dual-coding is consistent with the tRNA-loss driven codon reassignment hypothesis and provides a unique example of a proteome that cannot be deterministically predicted.
  • SpeciesList: scientific name: Babjeviella inositovora NRRL Y-12698; NCBI TaxID: 984486; scientific name: Nakazawaea peltata; NCBI TaxID: 1538182; scientific name: Ascoidea rubescens DSM 1968; NCBI TaxID: 1344418; scientific name: Clavispora lusitaniae ATCC 42720; NCBI TaxID: 306902; scientific name: Saccharomycopsis malanga; NCBI TaxID: 44092; scientific name: Ascoidea asiatica; NCBI TaxID: 1301101; scientific name: Saccharomycopsis fibuligera; NCBI TaxID: 4944;
  • ModificationList: N-acetylated residue; monohydroxylated residue
  • Instrument: Q Exactive

Dataset History

VersionDatetimeStatusChangeLog Entry
02018-04-13 02:19:21ID requested
12018-06-13 07:40:28announced
22018-06-20 00:20:17announcedUpdated publication reference for PubMed record(s): 29910077.

Publication List

  1. Mühlhausen S, Schmitt HD, Pan KT, Plessmann U, Urlaub H, Hurst LD, Kollmar M, Endogenous Stochastic Decoding of the CUG Codon by Competing Ser- and Leu-tRNAs in Ascoidea asiatica. Curr Biol, 28(13):2046-2057.e5(2018) [pubmed]

Keyword List

  1. curator keyword: Biological
  2. submitter keyword: Ascoidea, Saccharomycopsis, Nakazawaea, Babjeviella, Clavispora

Contact List

    Martin Kollmar
    • contact affiliation: Group Systems Biology of Motor Proteins, Department of NMR-based Structural Biology, Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany
    • contact email: mako@nmr.mpibpc.mpg.de
    • lab head:
    Martin Kollmar
    • contact affiliation: MPI for Biophysical Chemistry
    • contact email: mako@nmr.mpibpc.mpg.de
    • dataset submitter:

Full Dataset Link List

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