PXD009442

PXD009442 is an original dataset announced via ProteomeXchange.

Title	Linezolid suppresses growth of tumours dervived from triple negative breast cancer, cancer chemoresistant and cancer stem-like cells through the induction of mitochondrial dysfunction
Description	Cancer cells are known to reprogram their metabolism to adapt to adverse conditions dictated by tumor growth and microenvirontment. A subtype of cancer cells with stem-like properties, known as cancer stem cells (CSC) is thought to be responsible for tumour recurrence. These consequences are fatal for cancer patients as metastatic tumors are much more aggressive than the primary tumors from which they originate. Since both CSC and chemoresistant cancer cells may share common qualities and implicate involvement of mitochondria, drugs inducing mitochondrial dysfunction as for example, bactericidal antibiotics, may effectively suppress growth of cancer cells. In the current study, we demonstrate that CSC and chemoresistant cells derived from triple negative breast cancer (TNBC) cells display enrichment of up- and down-regulated proteins from metabolic pathways that suggest a direct link to mitochondria. Both cancer cell types (resistant cells and CSC) can be targeted by antibiotics, in particular, linezolid which decreases tumour growth rate by suppressing mitochondrial functions. As autophagy itself can “feed” cancer cells in their trial to reduce ROS induction by antibiotics, we propose that specific bactericidal antibiotics used in combination with autophagy blocker may suppress cancer cell proliferation and decrease tumour growth.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:44:18.634.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	David Potesil
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2018-04-09 03:31:26	ID requested
1	2018-11-04 14:04:30	announced
⏵ 2	2024-10-22 04:44:24	announced	2024-10-22: Updated project metadata.

10.1074/mcp.ra118.001102;

Abad E, Garc, í, a-Mayea Y, Mir C, Sebastian D, Zorzano A, Potesil D, Zdrahal Z, Lyakhovich A, Lleonart ME, Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer. Mol Cell Proteomics, 18(2):231-244(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Autophagy, Cancer stem cells, ROS,Cancer, Therapy resistance, Antibiotics, LC-MS/MS

Zbynek Zdrahal
contact affiliation	Proteomics - Zbyněk Zdráhal, CEITEC-MU, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic
contact email	zdrahal@sci.muni.cz
lab head
David Potesil
contact affiliation	Proteomics Core Facility and Research Group Proteomics CEITEC-MU Masaryk University Brno, Czech Republic
contact email	david.potesil@ceitec.muni.cz
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/11/PXD009442

PRIDE project URI

• PRIDE
  1. PXD009442
     1. Label: PRIDE project
     2. Name: Linezolid suppresses growth of tumours dervived from triple negative breast cancer, cancer chemoresistant and cancer stem-like cells through the induction of mitochondrial dysfunction