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PXD009434

DataSet Summary

  • HostingRepository: PRIDE
  • AnnounceDate: 2019-03-15
  • AnnouncementXML: Submission_2019-03-15_03:22:54.xml
  • DigitalObjectIdentifier:
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original data
  • RepositorySupport: Unsupported dataset by repository
  • PrimarySubmitter: Johannes R. Schmidt
  • Title: Synergistic potential of sulfated hyaluronic acid and dexamethasone
  • Description: Both sulfated hyaluronic acid and dexamethasone are candidates for the functionalization of bone grafts as they were shown to enhance the differentiation of osteoblasts from bone marrow stromal cells in vitro and in vivo. However, the underlying mechanisms are not fully understood. Furthermore, studies combining different approaches to assess to synergistic potentials are rare. In this study, we aim gain insights into the mode-of-action of both sulfated hyaluronic acid and dexamethasone by a comprehensive analysis of the cellular fraction, released matrix vesicles and the extracellular matrix, combining classical biochemical assays with mass spectrometry-based proteomics and further supported by novel bioinformatical computation.
  • SpeciesList: scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
  • ModificationList: monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
  • Instrument: LTQ XL ETD

Dataset History

VersionDatetimeStatusChangeLog Entry
02018-04-09 00:31:40ID requested
12019-03-15 03:22:55announced

Publication List

  1. Schmidt JR, Vogel S, Moeller S, Kalkhof S, Schubert K, von Bergen M, Hempel U, Sulfated hyaluronic acid and dexamethasone possess a synergistic potential in the differentiation of osteoblasts from human bone marrow stromal cells. J Cell Biochem, ():(2018) [pubmed]

Keyword List

  1. curator keyword: Biological, Biomedical
  2. submitter keyword: Human, osteoblasts, hBMSC, LC-MSMS, Sulfated hyluronic acid, dexamethasone

Contact List

    Kristin Schubert
    • contact affiliation: Helmholtz Centre for Environmental Research - UFZ Department for Molecular Systems Biology (MOLSYB) Functional genomics group Leipzig/Germany
    • contact email: kristin.schubert@ufz.de
    • lab head:
    Johannes R. Schmidt
    • contact affiliation: Helmholtz Centre for Environmental Research - UFZ
    • contact email: johannes.schmidt@ufz.de
    • dataset submitter:

Full Dataset Link List

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  2. PRIDE project URI
Repository Record List
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