PXD009434

PXD009434 is an original dataset announced via ProteomeXchange.

Title	Synergistic potential of sulfated hyaluronic acid and dexamethasone
Description	Both sulfated hyaluronic acid and dexamethasone are candidates for the functionalization of bone grafts as they were shown to enhance the differentiation of osteoblasts from bone marrow stromal cells in vitro and in vivo. However, the underlying mechanisms are not fully understood. Furthermore, studies combining different approaches to assess to synergistic potentials are rare. In this study, we aim gain insights into the mode-of-action of both sulfated hyaluronic acid and dexamethasone by a comprehensive analysis of the cellular fraction, released matrix vesicles and the extracellular matrix, combining classical biochemical assays with mass spectrometry-based proteomics and further supported by novel bioinformatical computation.
HostingRepository	PRIDE
AnnounceDate	2019-03-15
AnnouncementXML	Submission_2019-03-15_03:22:54.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Johannes R. Schmidt
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	LTQ XL ETD

Revision	Datetime	Status	ChangeLog Entry
0	2018-04-09 00:31:40	ID requested
⏵ 1	2019-03-15 03:22:55	announced

Schmidt JR, Vogel S, Moeller S, Kalkhof S, Schubert K, von Bergen M, Hempel U, Sulfated hyaluronic acid and dexamethasone possess a synergistic potential in the differentiation of osteoblasts from human bone marrow stromal cells. J Cell Biochem, 120(5):8706-8722(2019) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Human, osteoblasts, hBMSC, LC-MSMS, Sulfated hyluronic acid, dexamethasone

Kristin Schubert
contact affiliation	Helmholtz Centre for Environmental Research - UFZ Department for Molecular Systems Biology (MOLSYB) Functional genomics group Leipzig/Germany
contact email	kristin.schubert@ufz.de
lab head
Johannes R. Schmidt
contact affiliation	Helmholtz Centre for Environmental Research - UFZ
contact email	johannes.schmidt@ufz.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD009434

PRIDE project URI

• PRIDE
  1. PXD009434
     1. Label: PRIDE project
     2. Name: Synergistic potential of sulfated hyaluronic acid and dexamethasone