PXD009393

PXD009393 is an original dataset announced via ProteomeXchange.

Title	Proteome analysis of microvessels from CADASIL patients
Description	CADASIL, the most frequent and intensely studied monogenic SVD, is characterized by a severe pathology in the cerebral vasculature including the mutation-induced aggregation of the Notch3 extracellular domain (Notch3ECD) and the formation of protein deposits of insufficiently determined composition in the extracellular space of vessel walls. To advance our understanding of protein accumulation in CADASIL-affected tissue, we quantitatively determined the proteome of cerebral vessels isolated from patient and control autopsy samples (n = 6 for each group), obtaining 95 proteins with significantly increased abundance.
HostingRepository	PRIDE
AnnounceDate	2018-08-03
AnnouncementXML	Submission_2018-08-03_08:00:48.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Stephan Mueller
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-04-04 04:10:39	ID requested
⏵ 1	2018-08-03 08:00:49	announced

Zellner A, Scharrer E, Arzberger T, Oka C, Domenga-Denier V, Joutel A, Lichtenthaler SF, M, ü, ller SA, Dichgans M, Haffner C, CADASIL brain vessels show a HTRA1 loss-of-function profile. Acta Neuropathol, 136(1):111-125(2018) [pubmed]

curator keyword: Biological

submitter keyword: human, microvessels, CADASIL, small vessel disease

Christof Haffner
contact affiliation	Institute for Stroke and Dementia Research (ISD) Klinikum der Universität München Feodor-Lynen-Str. 17 81377 Munich Germany
contact email	christof.haffner@med.uni-muenchen.de
lab head
Stephan Mueller
contact affiliation	DZNE Munich Neuroproteomics
contact email	stephan.mueller@dzne.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/08/PXD009393

PRIDE project URI

• PRIDE
  1. PXD009393
     1. Label: PRIDE project
     2. Name: Proteome analysis of microvessels from CADASIL patients