PXD009374 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Quantitative phosphoproteomic for CDKL5 substrates |
Description | Global phosphoproteomic screen to identify the first cellular substrates of CDKL5. CDKL5 knock-out U2OS cells and CDKL5 wt U2OS cells were generated for the TMT-based phosphoproteomic. Thi leads to the identification and further validation of several phosphopetides of MAP1S, CEP131 and CDKL5 itself. The phosphoproteomic analysis allowed the identification of the first cellular substrates for CDKL5 kinase. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:44:08.759.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Matthias Trost |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue; deamidated residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-04-03 08:12:55 | ID requested | |
1 | 2018-09-24 04:05:16 | announced | |
2 | 2019-06-17 03:28:39 | announced | Updated publication reference for PubMed record(s): 30266825. |
⏵ 3 | 2024-10-22 04:44:16 | announced | 2024-10-22: Updated project metadata. |
Publication List
Mu, ñ, oz IM, Morgan ME, Peltier J, Weiland F, Gregorczyk M, Brown FC, Macartney T, Toth R, Trost M, Rouse J, Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase. EMBO J, 37(24):(2018) [pubmed] |
10.15252/embj.201899559; |
Keyword List
curator keyword: Biological |
submitter keyword: CDKL5 substrates,phosphoproteomic,TMT, MS2 |
Contact List
Matthias Trost |
contact affiliation | Newcastle university, ICAMB Newcastle Upon tyne, United Kingdom |
contact email | matthias.trost@ncl.ac.uk |
lab head | |
Matthias Trost |
contact affiliation | Newcastle University |
contact email | matthias.trost@ncl.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD009374
- Label: PRIDE project
- Name: Quantitative phosphoproteomic for CDKL5 substrates