PXD009361

PXD009361 is an original dataset announced via ProteomeXchange.

Title	The platelet releasate (PR) in human pregnancy
Description	Healthy pregnancy is characterized by an increase in platelet activation and a decrease in the number of circulating platelets with gestation. Despite this recognised importance, proteomic studies investigating platelets in healthy pregnancy have not been performed. As platelet cargo can be altered in different conditions, we hypothesised that platelets may store a relevant and bespoke collection of molecules during pregnancy. To examine this, we performed comparative label-free quantitative proteomic profiling of platelet releasates from healthy pregnant and non-pregnant women using a tandem mass spectrometry approach. Of the 723 proteins identified, 69 PR proteins were found to be differentially released from platelets in pregnancy, including proteins only expressed during pregnancy such as pregnancy-specific glycoproteins and human placental lactogen.
HostingRepository	PRIDE
AnnounceDate	2020-06-05
AnnouncementXML	Submission_2020-06-04_22:17:51.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Paulina Szklanna
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-03-28 08:47:50	ID requested
⏵ 1	2020-06-04 22:17:52	announced

Szklanna PB, Parsons ME, Wynne K, O'Connor H, Egan K, Allen S, N, í, , Á, inle F, Maguire PB, The Platelet Releasate is Altered in Human Pregnancy. Proteomics Clin Appl, 13(3):e1800162(2019) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Platelets, platelet releasate, pregnancy, label-free quantitation, mass spectrometry

Patricia B. Maguire
contact affiliation	University College Dublin, SBBS, Conway Institute, Dublin
contact email	patricia.maguire@ucd.ie
lab head
Paulina Szklanna
contact affiliation	University College Dublin
contact email	paulina.szklanna@ucdconnect.ie
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/06/PXD009361

PRIDE project URI

• PRIDE
  1. PXD009361
     1. Label: PRIDE project
     2. Name: The platelet releasate (PR) in human pregnancy