PXD009350

PXD009350 is an original dataset announced via ProteomeXchange.

Title	Proteomics at large: Discovery and replication of plasma proteomic biomarkers in independent cohorts - Overweight and obese patients of the Weight Management Clinical program of The Ottawa Hospital
Description	Holistic human proteome maps are expected to complement comprehensive profile assessment of health and disease phenotypes. However, methodologies to analyze proteomes in human tissue or body fluid samples at relevant scale and performance are still limited in clinical research. Their deployment and demonstration in large enough human populations are even sparser. In the present study, we have characterized and compared the plasma proteomes of two large independent cohorts of obese and overweight individuals using shotgun MS-based proteomics. One cohort comes from a Canadian single-center clinical weight management program while the other one belongs to a multicenter pan-European weight loss study (i.e., the DiOGenes study for which MS proteomic data have been already deposited to the ProteomeXchange Consortium with the dataset identifier PXD005216). The MS proteomic data deposited herein corresponds to the cohort coming from the Weight Management Clinical program of The Ottawa Hospital.
HostingRepository	PRIDE
AnnounceDate	2018-11-23
AnnouncementXML	Submission_2018-11-23_06:45:42.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD009350
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Loïc Dayon
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Ammonia-loss; Deamidated; TMT6plex; Dehydrated; Oxidation; Acetyl; Carbamidomethyl
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2018-03-28 01:15:49	ID requested
⏵ 1	2018-11-23 06:45:44	announced

Cominetti O, N, ú, ñ, ez Galindo A, Corth, é, sy J, Valsesia A, Irincheeva I, Kussmann M, Saris WHM, Astrup A, McPherson R, Harper ME, Dent R, Hager J, Dayon L, Obesity shows preserved plasma proteome in large independent clinical cohorts. Sci Rep, 8(1):16981(2018) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Biomarker, Mass spectrometry, Plasma association map, Proteomics, Obesity, Overweight, Replication

Loïc Dayon
contact affiliation	Proteomics Team, Nestlé Institute of Health Sciences, Lausanne, Switzerland
contact email	loic.dayon@rd.nestle.com
lab head
Loïc Dayon
contact affiliation	Nestlé Institute of Health Sciences SA
contact email	loic.dayon@rd.nestle.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/11/PXD009350

PRIDE project URI

• PRIDE
  1. PXD009350
     1. Label: PRIDE project
     2. Name: Proteomics at large: Discovery and replication of plasma proteomic biomarkers in independent cohorts - Overweight and obese patients of the Weight Management Clinical program of The Ottawa Hospital