PXD009321

PXD009321 is an original dataset announced via ProteomeXchange.

Title	Human cytomegalovirus alters the peroxisome proteome
Description	Peroxisomes are primarily metabolic organelles with important functions in lipid metabolism, such as fatty acid oxidation and ether phospholipid synthesis (e.g., plasmalogens). Certain viruses, such as human cytomegalovirus (HCMV), hijack organelle functions to facilitate their replication and spread. However, the role of peroxisomes in herpesvirus replication remains elusive. Therefore, we used targeted mass spectrometry to quantify 60 peroxisome proteins through the HCMV infection cycle. We provide two proteomic experiments. The first experiment (raw files labeled as 20180123) is of samples in biological triplicate from uninfected human fibroblasts and infected human fibroblasts at 6, 24, 48, 72, and 120 hours post infection. The second experiment (raw files labeled as 201806) is from uninfected/infected fibroblasts during phosphonoformate (PFA) treatment and fibroblasts infected with UV-treated HCMV.
HostingRepository	PRIDE
AnnounceDate	2018-10-04
AnnouncementXML	Submission_2018-10-04_08:32:56.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pierre Jean Beltran
SpeciesList	scientific name: Human herpesvirus 5 strain AD169; NCBI TaxID: 10360; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-03-26 01:25:41	ID requested
⏵ 1	2018-10-04 08:32:58	announced

Jean Beltran PM, Cook KC, Hashimoto Y, Galitzine C, Murray LA, Vitek O, Cristea IM, Infection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication. Cell Host Microbe, 24(4):526-541.e7(2018) [pubmed]

submitter keyword: Human, virus, HCMV, cytomegalovirus, PRM, peroxisome, fibroblast

Ileana Cristea
contact affiliation	Molecular Biology Department, Princeton University, Princeton, NJ, USA
contact email	icristea@princeton.edu
lab head
Pierre Jean Beltran
contact affiliation	Princeton University
contact email	pierrej@princeton.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD009321
     1. Label: PRIDE project
     2. Name: Human cytomegalovirus alters the peroxisome proteome