PXD009277 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Development of a parallel reaction monitoring-MS method to quantify IGF proteins in dogs: application to a canine case study of NICTH syndrome |
Description | Non–islet-cell tumor hypoglycemia (NICTH) is a rare paraneoplastic phenomenon seen in both dogs and humans. NICTH syndrome is derived from incompletely processed forms of insulin-like growth factor–II (IGF–II) by tumors, commonly named as big IGF–II. In the present study, a previously developed targeted PRM MS-based method for cats have been optimized and applied to simultaneously quantify the levels of IGF–I, IGF–II, and IGFBP–3, and for the first time, the levels of big IGF–II in dogs. This method allows the absolute quantification of these proteins using a mixture of QPrEST™ proteins previously designed for humans, reducing the variations due to the methodology, and the amount of serum needed for the analysis. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:44:14.512.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Alberto Valdés |
SpeciesList | scientific name: Canis familiaris (Dog) (Canis lupus familiaris); NCBI TaxID: 9615; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-03-21 03:22:05 | ID requested | |
1 | 2018-11-04 13:31:30 | announced | |
⏵ 2 | 2024-10-22 04:44:22 | announced | 2024-10-22: Updated project metadata. |
Publication List
Vald, é, s A, Lewitt M, Wiss E, Ramstr, ö, m M, Strage EM, Development of a Parallel Reaction Monitoring-MS Method To Quantify IGF Proteins in Dogs and a Case of Nonislet Cell Tumor Hypoglycemia. J Proteome Res, 18(1):18-29(2019) [pubmed] |
10.1021/acs.jproteome.8b00259; |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: Dog proteomics, NICTH, PRM, IGF |
Contact List
Emma M. Strage |
contact affiliation | Department of Clinical Sciences, and Clinical Pathology Laboratory, University Animal Hospital, Swedish University of Agricultural Sciences, Uppsala, Sweden. |
contact email | Emma.Strage@uds.slu.se |
lab head | |
Alberto Valdés |
contact affiliation | Department of Chemistry-BMC, Analytical Chemistry, Uppsala University, Uppsala, Sweden |
contact email | a.valdes@csic.es |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD009277
- Label: PRIDE project
- Name: Development of a parallel reaction monitoring-MS method to quantify IGF proteins in dogs: application to a canine case study of NICTH syndrome