PXD009251

PXD009251 is an original dataset announced via ProteomeXchange.

Title	Comparative hippocampal synaptic proteomes of rodents and primates: differences in neuroplasticity-related proteins
Description	Key to the human brain’s unique capacities are a myriad of neural cell types, specialized molecular expression signatures, and complex patterns of neuronal connectivity. Neurons in the human brain communicate via well over a quadrillion synapses. Their specific contribution might be key to the dynamic activity patterns that underlie primate-specific cognitive function. Recently, functional differences were described in transmission capabilities of human and rat synapses. To test whether unique expression signatures of synaptic proteins are at the basis of this, we performed a quantitative analysis of the hippocampal synaptic proteome of four mammalian species, two primates, human and marmoset, and two rodents, rat and mouse. Abundance differences down to 1.15-fold at an FDR-corrected p-value of 0.005 were reliably detected using SWATH mass spectrometry. The high measurement accuracy of SWATH allowed the detection of a large group of differentially expressed proteins between individual species and rodent versus primate. Differentially expressed proteins between rodent and primate were found highly enriched for plasticity-related proteins.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:44:11.418.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Frank Koopmans
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: marmosets; NCBI TaxID: 38020; scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	L-cysteine methyl disulfide; monohydroxylated residue; acetylated residue
Instrument	Orbitrap Fusion Lumos; TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2018-03-19 02:57:41	ID requested
1	2018-10-22 01:17:06	announced
⏵ 2	2024-10-22 04:44:16	announced	2024-10-22: Updated project metadata.

Koopmans F, Pandya NJ, Franke SK, Phillippens IHCMH, Paliukhovich I, Li KW, Smit AB, Comparative Hippocampal Synaptic Proteomes of Rodents and Primates: Differences in Neuroplasticity-Related Proteins. Front Mol Neurosci, 11():364(2018) [pubmed]

10.3389/fnmol.2018.00364;

curator keyword: Biological

submitter keyword: synapse, species, proteomics, rat, marmoset, human, synaptosome, mouse,SWATH

Ka Wan Li
contact affiliation	Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, The Netherlands
contact email	k.w.li@vu.nl
lab head
Frank Koopmans
contact affiliation	VU University
contact email	frank.koopmans@vu.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD009251

PRIDE project URI

• PRIDE
  1. PXD009251
     1. Label: PRIDE project
     2. Name: Comparative hippocampal synaptic proteomes of rodents and primates: differences in neuroplasticity-related proteins