PXD009251 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Comparative hippocampal synaptic proteomes of rodents and primates: differences in neuroplasticity-related proteins |
Description | Key to the human brain’s unique capacities are a myriad of neural cell types, specialized molecular expression signatures, and complex patterns of neuronal connectivity. Neurons in the human brain communicate via well over a quadrillion synapses. Their specific contribution might be key to the dynamic activity patterns that underlie primate-specific cognitive function. Recently, functional differences were described in transmission capabilities of human and rat synapses. To test whether unique expression signatures of synaptic proteins are at the basis of this, we performed a quantitative analysis of the hippocampal synaptic proteome of four mammalian species, two primates, human and marmoset, and two rodents, rat and mouse. Abundance differences down to 1.15-fold at an FDR-corrected p-value of 0.005 were reliably detected using SWATH mass spectrometry. The high measurement accuracy of SWATH allowed the detection of a large group of differentially expressed proteins between individual species and rodent versus primate. Differentially expressed proteins between rodent and primate were found highly enriched for plasticity-related proteins. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:44:11.418.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Frank Koopmans |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: marmosets; NCBI TaxID: 38020; scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | L-cysteine methyl disulfide; monohydroxylated residue; acetylated residue |
Instrument | Orbitrap Fusion Lumos; TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-03-19 02:57:41 | ID requested | |
1 | 2018-10-22 01:17:06 | announced | |
⏵ 2 | 2024-10-22 04:44:16 | announced | 2024-10-22: Updated project metadata. |
Publication List
Koopmans F, Pandya NJ, Franke SK, Phillippens IHCMH, Paliukhovich I, Li KW, Smit AB, Comparative Hippocampal Synaptic Proteomes of Rodents and Primates: Differences in Neuroplasticity-Related Proteins. Front Mol Neurosci, 11():364(2018) [pubmed] |
10.3389/fnmol.2018.00364; |
Keyword List
curator keyword: Biological |
submitter keyword: synapse, species, proteomics, rat, marmoset, human, synaptosome, mouse,SWATH |
Contact List
Ka Wan Li |
contact affiliation | Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, The Netherlands |
contact email | k.w.li@vu.nl |
lab head | |
Frank Koopmans |
contact affiliation | VU University |
contact email | frank.koopmans@vu.nl |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD009251
- Label: PRIDE project
- Name: Comparative hippocampal synaptic proteomes of rodents and primates: differences in neuroplasticity-related proteins