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PXD009251

PXD009251 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleComparative hippocampal synaptic proteomes of rodents and primates: differences in neuroplasticity-related proteins
DescriptionKey to the human brain’s unique capacities are a myriad of neural cell types, specialized molecular expression signatures, and complex patterns of neuronal connectivity. Neurons in the human brain communicate via well over a quadrillion synapses. Their specific contribution might be key to the dynamic activity patterns that underlie primate-specific cognitive function. Recently, functional differences were described in transmission capabilities of human and rat synapses. To test whether unique expression signatures of synaptic proteins are at the basis of this, we performed a quantitative analysis of the hippocampal synaptic proteome of four mammalian species, two primates, human and marmoset, and two rodents, rat and mouse. Abundance differences down to 1.15-fold at an FDR-corrected p-value of 0.005 were reliably detected using SWATH mass spectrometry. The high measurement accuracy of SWATH allowed the detection of a large group of differentially expressed proteins between individual species and rodent versus primate. Differentially expressed proteins between rodent and primate were found highly enriched for plasticity-related proteins.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:44:11.418.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterFrank Koopmans
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: marmosets; NCBI TaxID: 38020; scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListL-cysteine methyl disulfide; monohydroxylated residue; acetylated residue
InstrumentOrbitrap Fusion Lumos; TripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-03-19 02:57:41ID requested
12018-10-22 01:17:06announced
22024-10-22 04:44:16announced2024-10-22: Updated project metadata.
Publication List
Koopmans F, Pandya NJ, Franke SK, Phillippens IHCMH, Paliukhovich I, Li KW, Smit AB, Comparative Hippocampal Synaptic Proteomes of Rodents and Primates: Differences in Neuroplasticity-Related Proteins. Front Mol Neurosci, 11():364(2018) [pubmed]
10.3389/fnmol.2018.00364;
Keyword List
curator keyword: Biological
submitter keyword: synapse, species, proteomics, rat, marmoset, human, synaptosome, mouse,SWATH
Contact List
Ka Wan Li
contact affiliationDepartment of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, The Netherlands
contact emailk.w.li@vu.nl
lab head
Frank Koopmans
contact affiliationVU University
contact emailfrank.koopmans@vu.nl
dataset submitter
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Dataset FTP location
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PRIDE project URI
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