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PXD009219

PXD009219 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe difference in serum proteomes in schizophrenia and bipolar disorder
DescriptionPurpose of study is revealing significant differences in serum proteomes in schizophrenia, bipolar disorder (BD), and matched healthy controls. The sample preparation included affinity removing of six major proteins, separation by 1D electrophoresis, in-gel tryptic hydrolysis, and LC-MS/MS peptide analysis using LTQ Orbitrap Velos mass spectrometer. When comparing proteome profiles, different unique protein sets were revealed (absent in other groups): 22 proteins typical for schizophrenia, and 20 – for BD. Protein set in schizophrenia was mostly associated with nucleic acid and protein metabolism, immune response, cell communication, and cell growth and maintenance. Protein set in BD was mostly associated with cell growth and maintenance, nucleic acid metabolism regulation, immune response, protein metabolism, transport and cell communication. Concentrations of ankyrin repeat domain-containing protein 12 (ANKRD12), coagulation factor XIII, and cadherin 5 in serum samples were determined by ELISA. Significant difference between three groups was revealed in ANKRD12 concentration (p=0.02), with maximum elevation of ANKRD12 concentration (median level) in schizophrenia followed by BD. Cadherin 5 concentration differed significantly (p=0.035) between schizophrenic patients with prevailing positive symptoms (4.78 [2.71;7.12] ng/ml) and those with prevailing negative symptoms (1.86 [0.001;4.11] ng/ml). Our results are presumably useful for discovering the new pathways involved in endogenous psychotic disorders.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:43:40.710.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAlexandr Seregin
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-03-15 07:09:33ID requested
12019-11-12 10:41:08announced
22024-10-22 04:43:43announced2024-10-22: Updated project metadata.
Publication List
Smirnova L, Seregin A, Boksha I, Dmitrieva E, Simutkin G, Kornetova E, Savushkina O, Letova A, Bokhan N, Ivanova S, Zgoda V, The difference in serum proteomes in schizophrenia and bipolar disorder. BMC Genomics, 20(Suppl 7):535(2019) [pubmed]
10.1186/s12864-019-5848-1;
Keyword List
curator keyword: Biological, Biomedical
submitter keyword: one- dimensional gel electrophoresis, schizophrenia, proteomics, mass spectrometry, serum,biomarker, proteome, bipolar disorder
Contact List
Svetlana Ivanova
contact affiliationLaboratory of Molecular Genetics and Biochemistry, Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
contact emailivanovaniipz@gmail.com
lab head
Alexandr Seregin
contact affiliationTomsk National Research Medical Center of the Russian Academy of Sciences
contact emailapocalips1991@mail.ru
dataset submitter
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Dataset FTP location
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PRIDE project URI
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