PXD009212

PXD009212 is an original dataset announced via ProteomeXchange.

Title	Proteome profiling in aging rat brain by LC-MS/MS
Description	This study investigated proteome profile in the hippocampus, medial prefrontal cortex (mPFC), and striatum of 14, 18, 23, and 27 months old rats in order to see the effect of aging on proteins in these regions. Using ultrahigh performance liquid chromatography coupled with Q Exactive HF Orbitrap mass spectrometry, we identified 1074 proteins in the hippocampus, 871 proteins in the mPFC, and 241 proteins the striatum. Ninety-seven, 25, and 5 of these proteins were differentially expressed with age in the hippocampus, mPFC, and striatum, respectively. Overall, aging causes divergent protein changes in specific brain regions, with the most prominent changes observed in the late-aged.
HostingRepository	PRIDE
AnnounceDate	2018-07-12
AnnouncementXML	Submission_2018-08-13_12:33:13.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hamizah Shahirah Hamezah
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-03-14 10:52:16	ID requested
1	2018-07-12 05:03:52	announced
⏵ 2	2018-08-13 12:33:14	announced	Updated publication reference for PubMed record(s): 29981398.

Hamezah HS, Durani LW, Yanagisawa D, Ibrahim NF, Aizat WM, Bellier JP, Makpol S, Ngah WZW, Damanhuri HA, Tooyama I, Proteome profiling in the hippocampus, medial prefrontal cortex, and striatum of aging rat. Exp Gerontol, 111():53-64(2018) [pubmed]

curator keyword: Biological

submitter keyword: Rat, Brain, Aging, Proteomics

Ikuo Tooyama
contact affiliation	Molecular Neuroscience Research Center, Shiga University of Medical Science, Japan
contact email	kinchan@belle.shiga-med.ac.jp
lab head
Hamizah Shahirah Hamezah
contact affiliation	Shiga University of Medical Science
contact email	hamiza49@belle.shiga-med.ac.jp
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/07/PXD009212

PRIDE project URI

• PRIDE
  1. PXD009212
     1. Label: PRIDE project
     2. Name: Proteome profiling in aging rat brain by LC-MS/MS