PXD009197

PXD009197 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	In vitro blood-brain barrier model proteome influenced by silver nanoparticles
Description	Silver nanoparticles (AgNP) have been reported to penetrate the central nervous system and induce neurotoxicity. However, there is paucity in understanding the toxicity of AgNPs and their effect on the blood-brain barrier (BBB) including the underlying molecular mechanism(s) of action. Using an in vitro BBB model and mass spectrometry based proteomics we investigated the alteration in the proteome pathways of the brain endothelial cells and astrocytes exposed to AgNPs for 24 and 48 hours.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:43:40.321.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vladimir Gorshkov
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; iodoacetic acid derivatized residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-03-13 05:05:18	ID requested
1	2018-11-07 02:10:07	announced
2	2019-01-16 00:29:19	announced	Updated publication reference for PubMed record(s): 30623748.
⏵ 3	2024-10-22 04:43:48	announced	2024-10-22: Updated project metadata.

Publication List

Khan AM, Korzeniowska B, Gorshkov V, Tahir M, Schr, ø, der H, Skytte L, Rasmussen KL, Khandige S, M, ø, ller-Jensen J, Kjeldsen F, Silver nanoparticle-induced expression of proteins related to oxidative stress and neurodegeneration in an in vitro human blood-brain barrier model. Nanotoxicology, 13(2):221-239(2019) [pubmed]
10.1080/17435390.2018.1540728;

Khan AM, Korzeniowska B, Gorshkov V, Tahir M, Schr, ø, der H, Skytte L, Rasmussen KL, Khandige S, M, ø, ller-Jensen J, Kjeldsen F, Silver nanoparticle-induced expression of proteins related to oxidative stress and neurodegeneration in an in vitro human blood-brain barrier model. Nanotoxicology, 13(2):221-239(2019) [pubmed]

10.1080/17435390.2018.1540728;

Keyword List

curator keyword: Biological, Biomedical
submitter keyword: silver, TMT, LC-MS, nanoparticles,human, blood-brain barrier

curator keyword: Biological, Biomedical

submitter keyword: silver, TMT, LC-MS, nanoparticles,human, blood-brain barrier

Contact List

Frank Kjeldsen
contact affiliation	Department for Biochemistry and Molecular Biology University of Southern Denmark Odense, Denmark
contact email	frankk@bmb.sdu.dk
lab head
Vladimir Gorshkov
contact affiliation	University of Southern Denmark
contact email	vgor@bmb.sdu.dk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/11/PXD009197
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/11/PXD009197

PRIDE project URI

Repository Record List

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