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PXD009175

PXD009175 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleKlebsiella pneumoniae protomic response to antibiotics
DescriptionBacteria can circumvent the effect of antibiotics by transitioning to a poorly understood physiological state that does not involve conventional genetic elements of resistance. Here we examine antibiotic susceptibility with a Class A β-lactamase+ invasive strain of Klebsiella pneumoniae that was isolated from a lethal outbreak within laboratory colonies of Chlorocebus aethiops sabaeus monkeys. Bacterial responses to the ribosomal synthesis inhibitors streptomycin and doxycycline resulted in distinct proteomic adjustments that facilitated decreased susceptibility to each antibiotic.
HostingRepositoryPRIDE
AnnounceDate2019-03-14
AnnouncementXMLSubmission_2019-03-14_03:04:54.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMoo-Jin Suh
SpeciesList scientific name: Klebsiella pneumoniae; NCBI TaxID: 573;
ModificationListiodoacetamide derivatized residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-03-12 02:00:20ID requested
12019-03-14 03:04:56announced
Publication List
Keasey SL, Suh MJ, Das S, Blancett CD, Zeng X, Andresson T, Sun MG, Ulrich RG, Proteome. Mol Cell Proteomics, 18(4):657-668(2019) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Klebsiella pneumoniae, LC-MS/MS, Doxycycline, Streptomycin
Contact List
Moojin Suh
contact affiliationU.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA
contact emailJinisuh@gmail.com
lab head
Moo-Jin Suh
contact affiliationUSAMRIID
contact emailjinisuh@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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