PXD009175 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Klebsiella pneumoniae protomic response to antibiotics |
Description | Bacteria can circumvent the effect of antibiotics by transitioning to a poorly understood physiological state that does not involve conventional genetic elements of resistance. Here we examine antibiotic susceptibility with a Class A β-lactamase+ invasive strain of Klebsiella pneumoniae that was isolated from a lethal outbreak within laboratory colonies of Chlorocebus aethiops sabaeus monkeys. Bacterial responses to the ribosomal synthesis inhibitors streptomycin and doxycycline resulted in distinct proteomic adjustments that facilitated decreased susceptibility to each antibiotic. |
HostingRepository | PRIDE |
AnnounceDate | 2019-03-14 |
AnnouncementXML | Submission_2019-03-14_03:04:54.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Moo-Jin Suh |
SpeciesList | scientific name: Klebsiella pneumoniae; NCBI TaxID: 573; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-03-12 02:00:20 | ID requested | |
⏵ 1 | 2019-03-14 03:04:56 | announced | |
Publication List
Keasey SL, Suh MJ, Das S, Blancett CD, Zeng X, Andresson T, Sun MG, Ulrich RG, Proteome. Mol Cell Proteomics, 18(4):657-668(2019) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Klebsiella pneumoniae, LC-MS/MS, Doxycycline, Streptomycin |
Contact List
Moojin Suh |
contact affiliation | U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA |
contact email | Jinisuh@gmail.com |
lab head | |
Moo-Jin Suh |
contact affiliation | USAMRIID |
contact email | jinisuh@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD009175 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD009175
- Label: PRIDE project
- Name: Klebsiella pneumoniae protomic response to antibiotics