PXD009148

PXD009148 is an original dataset announced via ProteomeXchange.

Title	The endosomal proteome of LAMTOR2-deficient primary macrophages
Description	A quantitative iTRAQ-based organelle proteomics analysis of endosomes derived from LAMTOR2-deficient macrophages has been performed. Primary macrophages were derived from bone marrow of conditional knockout mice carrying a specific deletion of LAMTOR2 in the monocyte/macrophage cell lineage. The combined proteomics and transcriptomics data indicated a function of LAMTOR2 in lipid metabolism.
HostingRepository	PRIDE
AnnounceDate	2019-08-26
AnnouncementXML	Submission_2019-08-26_00:34:38.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Taras Stasyk
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iTRAQ4plex-115 reporter fragment; monohydroxylated residue; iTRAQ4plex-116 reporter fragment; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-03-09 00:21:15	ID requested
⏵ 1	2019-08-26 00:34:40	announced

Lamberti G, De Smet CH, Angelova M, Kremser L, Taub N, Herrmann C, Hess MW, Rainer J, Tancevski I, Schweigreiter R, Kofler R, Schmiedinger T, Vietor I, Trajanoski Z, Ejsing CS, Lindner HH, Huber LA, Stasyk T, LAMTOR/Ragulator regulates lipid metabolism in macrophages and foam cell differentiation. FEBS Lett, 594(1):31-42(2020) [pubmed]

curator keyword: Biological

submitter keyword: LAMTOR, Ragulator, Organelle proteomics, Macrophages, foam cells

Lukas A. Huber
contact affiliation	Division of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria
contact email	lukas.a.huber@i-med.ac.at
lab head
Taras Stasyk
contact affiliation	Division of Cell Biology, Biocenter, Medical University of Innsbruck
contact email	taras.stasyk@i-med.ac.at
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/08/PXD009148

PRIDE project URI

• PRIDE
  1. PXD009148
     1. Label: PRIDE project
     2. Name: The endosomal proteome of LAMTOR2-deficient primary macrophages