<<< Full experiment listing

PXD009139

PXD009139 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleComparative serum proteomics of Intraductal papillary mucinous neoplasias and pacreatic adenocarcinoma
DescriptionIPMN tumors are considered precancerous and starting from low grade dysplasia some of them develop IPMN associated or concomitant pancreatic cancer. The prognosis of IPMN is good if the tumor is operated before malignant transformation occurs. On the other hand, not nearly all IPMNs undergo malignant transformation during the patient’s life time. differences in proteins found in serum samples could provide a way to differentiate IPMNs with different states of dysplasia. The aim of our study was to compare the serum protein profiles in sera of patients with IPMN with low or high grade dysplasia, IPMN associated carcinoma and healthy controls. We have quantified 436 serum proteins with two or more unique peptides from 55 serum samples including 11 healthy controls. These proteomic dataset was analyzed with advanced multivariate statistical data analysis techniques to find the protein features which could be used as potential biomarkers of various grades of dysplasia as well as to differentiate dysplasia samples from pancreatic carcinoma.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_06:52:26.235.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSakari Joenväärä
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentSynapt MS
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-03-08 01:54:56ID requested
12019-08-19 04:12:06announced
22019-12-13 04:28:27announced2019-12-13: Updated publication reference for DOI(s): 10.1186/s41231-019-0037-4.
32023-11-14 06:52:26announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
curator keyword: Biomedical
submitter keyword: UDHMSE, Label-free proteomics,Intraductal papillary mucinous neoplasias, Pancreatic adneocarcinoma
Contact List
Risto Renkonen
contact affiliationTransplantation Laboratory, Faculty of Medicine, University of Helsinki, Helsinki, Finland and HUSLAB, Helsinki University Hospital, Helsinki, Finland
contact emailristo.renkonen@helsinki.fi
lab head
Sakari Joenväärä
contact affiliationHelsinki University
contact emailsakari.joenvaara@helsinki.fi
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/08/PXD009139
PRIDE project URI
Repository Record List
[ + ]