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PXD009135

PXD009135 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIdentification of adsorbing human plasma proteins on alginate gel beads
DescriptionThe biocompatibility of immunoisolation devices is a major challenge for their use in cellular therapies. Utilisation of alginate for the encapsulation of pancreatic islets as a potential cellular therapy for type 1 diabetes has shown to be limited in terms of long-term graft survival, due to pericapsular fibrotic overgrowth. Fibrotic overgrowth is a complex process that involves several factors, including protein adsorption. This work investigates the protein adsorption profiles of plasma incubated alginate beads for the identification of key proteins that may play a role in the biocompatibility of this biomaterial.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_07:43:33.402.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAnimesh Sharma
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListdeamidated residue
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-03-08 01:27:14ID requested
12023-03-10 12:58:24announced
22023-11-14 07:43:38announced2023-11-14: Updated project metadata.
Publication List
Coron AE, Fonseca DM, Sharma A, Slupphaug G, Strand BL, Rokstad AMA, MS-proteomics provides insight into the host responses towards alginate microspheres. Mater Today Bio, 17():100490(2022) [pubmed]
Keyword List
curator keyword: Technical, Biomedical
submitter keyword: Alginate gel beads, biocompatibility, protein adsorption, proteomics
Contact List
Geir Slupphaug
contact affiliationProfessor i molekylærbiologi og faglig leder av PROMEC Institutt for klinisk og molekylær medisin Fakultet for medisin og helsevitenskap geir.slupphaug@ntnu.no 72573076 91825455 Laboratoriesenteret, 231.05.034, Øya, Erling Skjalgssons g 1
contact emailgeir.slupphaug@ntnu.no
lab head
Animesh Sharma
contact affiliationEngineer at NTNU, Norway
contact emailsharma.animesh@gmail.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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