PXD009135

PXD009135 is an original dataset announced via ProteomeXchange.

Title	Identification of adsorbing human plasma proteins on alginate gel beads
Description	The biocompatibility of immunoisolation devices is a major challenge for their use in cellular therapies. Utilisation of alginate for the encapsulation of pancreatic islets as a potential cellular therapy for type 1 diabetes has shown to be limited in terms of long-term graft survival, due to pericapsular fibrotic overgrowth. Fibrotic overgrowth is a complex process that involves several factors, including protein adsorption. This work investigates the protein adsorption profiles of plasma incubated alginate beads for the identification of key proteins that may play a role in the biocompatibility of this biomaterial.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_07:43:33.402.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Animesh Sharma
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	deamidated residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2018-03-08 01:27:14	ID requested
1	2023-03-10 12:58:24	announced
⏵ 2	2023-11-14 07:43:38	announced	2023-11-14: Updated project metadata.

Coron AE, Fonseca DM, Sharma A, Slupphaug G, Strand BL, Rokstad AMA, MS-proteomics provides insight into the host responses towards alginate microspheres. Mater Today Bio, 17():100490(2022) [pubmed]

curator keyword: Technical, Biomedical

submitter keyword: Alginate gel beads, biocompatibility, protein adsorption, proteomics

Geir Slupphaug
contact affiliation	Professor i molekylærbiologi og faglig leder av PROMEC Institutt for klinisk og molekylær medisin Fakultet for medisin og helsevitenskap geir.slupphaug@ntnu.no 72573076 91825455 Laboratoriesenteret, 231.05.034, Øya, Erling Skjalgssons g 1
contact email	geir.slupphaug@ntnu.no
lab head
Animesh Sharma
contact affiliation	Engineer at NTNU, Norway
contact email	sharma.animesh@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD009135

PRIDE project URI

• PRIDE
  1. PXD009135
     1. Label: PRIDE project
     2. Name: Identification of adsorbing human plasma proteins on alginate gel beads