PXD009126
PXD009126 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Black Phosphorus-Corona LC-MS/MS |
Description | The increasing number of biological applications for black phosphorus (BP) nanomaterials has precipitated considerable concern about their interactions with physiological systems. Here, we demonstrate the adsorption of plasma protein onto BP nanomaterials and the subsequent immune perturbation effect on macrophages. Using liquid chromatography tandem mass spectrometry, we discovered that BP nanosheets (BPNSs) were able to bind 23.3 percent of immune proteins from plasma, while BP quantum dots (BPQDs) bound 41.8 percent of immune proteins. In particular, the protein corona dramatically reshaped BP nanomaterial-corona complexes, influenced cellular uptake, activated the NF-κB pathway and even increased cytokine secretion by 2-5-fold. BP nanomaterials induced immunotoxicity and immune perturbation in macrophages in the presence of a plasma corona. These findings offer important insights into the development of safe and effective BP nanomaterial-based therapies. |
HostingRepository | iProX |
AnnounceDate | 2018-03-07 |
AnnouncementXML | Submission_2018-03-06_19:10:52.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jianbin Mo |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue; monohydroxylated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2018-03-06 19:10:42 | ID requested | |
⏵ 1 | 2018-03-06 19:10:53 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: black phosphorus nanomaterials, corona, human plasma, LC-MS/MS |
Contact List
Wei Wei | |
---|---|
contact affiliation | Nanjing University |
contact email | weiwei@nju.edu.cn |
lab head | |
Jianbin Mo | |
contact affiliation | Nanjing University |
contact email | 492704926@qq.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |