PXD009126

PXD009126 is an original dataset announced via ProteomeXchange.

Title	Black Phosphorus-Corona LC-MS/MS
Description	The increasing number of biological applications for black phosphorus (BP) nanomaterials has precipitated considerable concern about their interactions with physiological systems. Here, we demonstrate the adsorption of plasma protein onto BP nanomaterials and the subsequent immune perturbation effect on macrophages. Using liquid chromatography tandem mass spectrometry, we discovered that BP nanosheets (BPNSs) were able to bind 23.3 percent of immune proteins from plasma, while BP quantum dots (BPQDs) bound 41.8 percent of immune proteins. In particular, the protein corona dramatically reshaped BP nanomaterial-corona complexes, influenced cellular uptake, activated the NF-κB pathway and even increased cytokine secretion by 2-5-fold. BP nanomaterials induced immunotoxicity and immune perturbation in macrophages in the presence of a plasma corona. These findings offer important insights into the development of safe and effective BP nanomaterial-based therapies.
HostingRepository	iProX
AnnounceDate	2018-03-07
AnnouncementXML	Submission_2018-03-06_19:10:52.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jianbin Mo
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue; monohydroxylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-03-06 19:10:42	ID requested
⏵ 1	2018-03-06 19:10:53	announced

Dataset with its publication pending

submitter keyword: black phosphorus nanomaterials, corona, human plasma, LC-MS/MS

Wei Wei
contact affiliation	Nanjing University
contact email	weiwei@nju.edu.cn
lab head
Jianbin Mo
contact affiliation	Nanjing University
contact email	492704926@qq.com
dataset submitter

iProX dataset URI