PXD009102

PXD009102 is an original dataset announced via ProteomeXchange.

Title	Stress hormones induce breast intra-tumor heterogeneity
Description	Diversity within or between a tumour and metastases, known as intra-patient tumour heterogeneity develops during disease progression, and is a serious hurdle for therapy1,2,3. Metastasis is the fatal hallmark of cancer and mechanisms of colonization, the most complex step of the metastatic cascade4,5, remain ill-defined. Better understanding of cellular and molecular processes underlying intra-patient tumour heterogeneity and metastasis are pivotal for the success of personalized cancer treatment. Here, transcriptional profiling of tumours and matched metastases showed cancer site-specific phenotypes, and identified increased glucocorticoid receptor (GR) activity in the distant metastases. GR has been shown to mediate the effects of stress hormones and of their synthetic derivatives, widely used in the clinic as anti-inflammatory and immunosuppressive.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:43:30.175.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD009102
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Alexander Schmidt
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex; Oxidation; Carbamidomethyl
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-03-02 07:05:02	ID requested
1	2019-03-25 09:03:25	announced
⏵ 2	2024-10-22 04:43:37	announced	2024-10-22: Updated project metadata.

Obradovi, ć MMS, Hamelin B, Manevski N, Couto JP, Sethi A, Coissieux MM, M, ü, nst S, Okamoto R, Kohler H, Schmidt A, Bentires-Alj M, Glucocorticoids promote breast cancer metastasis. Nature, 567(7749):540-544(2019) [pubmed]

10.6019/PXD009102;

10.1038/s41586-019-1019-4;

curator keyword: Biomedical

submitter keyword: TMT,cancer, phosphoproteomics

Alexander Schmidt
contact affiliation	Biozentrum, University of Basel, Switzerland
contact email	alex.schmidt@unibas.ch
lab head
Alexander Schmidt
contact affiliation	Proteomics Core Facility
contact email	alex.schmidt@unibas.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD009102

PRIDE project URI

• PRIDE
  1. PXD009102
     1. Label: PRIDE project
     2. Name: Stress hormones induce breast intra-tumor heterogeneity