PXD009089

PXD009089 is an original dataset announced via ProteomeXchange.

Title	A multiomics approach in refractory DLBCL
Description	Diffuse large B-cell lymphoma (DLBCL) is the most frequent entity among non-Hodgkin lymphoma (NHL). It is a clinically and biologically heterogeneous disease regarding treatment response and long-term outcome. The anthracycline-based regimen R-CHOP is still considered as the standard of care for first-line treatment allowing achieving a complete response for approximately 60% of the patients. The prognosis of patients with primary refractory or relapsed (R/R) disease is particularly poor with a median overall survival below one year. Only a fraction of R/R patients can be cured with salvage therapies due to the acquisition of chemoresistance. We conducted a large-scale and deep proteomic investigation of the proteome profiles of R/R DLBCL patients compared to chemosensitive patients in order to identify new potential biomarkers related to resistance to treatment and to better understand the biological mechanisms underlying chemoresistance.
HostingRepository	PRIDE
AnnounceDate	2019-03-04
AnnouncementXML	Submission_2019-03-04_04:58:33.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Luc FORNECKER
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidoethyl-L-cysteine; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-03-02 01:34:02	ID requested
⏵ 1	2019-03-04 04:58:34	announced

Fornecker LM, Muller L, Bertrand F, Paul N, Pichot A, Herbrecht R, Chenard MP, Mauvieux L, Vallat L, Bahram S, Cianf, é, rani S, Carapito R, Carapito C, Multi-omics dataset to decipher the complexity of drug resistance in diffuse large B-cell lymphoma. Sci Rep, 9(1):895(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Human, lymph nodes, LC-MS/MS

Sarah Cianférani
contact affiliation	Laboratoire de Spectrométrie de Masse BioOrganique (LSMBO), IPHC, Université de Strasbourg, CNRS UMR7178, Strasbourg, France
contact email	sarah.cianferani@unistra.fr
lab head
Luc FORNECKER
contact affiliation	IPHC LSMBO Strasbourg
contact email	luc-matthieu.fornecker@chru-strasbourg.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD009089

PRIDE project URI

• PRIDE
  1. PXD009089
     1. Label: PRIDE project
     2. Name: A multiomics approach in refractory DLBCL