PXD009081

PXD009081 is an original dataset announced via ProteomeXchange.

Title	Oral Pathogen ‘Neutralizes’ the Human Innate Immune Defence
Description	Our present findings show for the first time that the virulence factor PPAD protects the oral pathogen P. gingivalis against neutrophil insults at three distinct levels, namely phagocytosis, NETosis and CAMP activity. This identifies PPAD as a major agent in the evasion of human innate immunity, a view that is supported by studies from Potempa and co-workers showing PPAD-dependent citrullination of complement.
HostingRepository	PRIDE
AnnounceDate	2018-10-15
AnnouncementXML	Submission_2018-10-15_01:15:23.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thomas Sura
SpeciesList	scientific name: Porphyromonas gingivalis (strain ATCC BAA-308 / W83); NCBI TaxID: 242619;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2018-03-01 02:04:40	ID requested
⏵ 1	2018-10-15 01:15:24	announced

Dataset with its publication pending

curator keyword: Biomedical

submitter keyword: citrullination, Porphyromonas gingivalis, proteome, peptidylarginine deiminase (PPAD)

Dörte Becher
contact affiliation	Universität Greifswald Hausdorffstrasse 8 17489 Greifswald Germany
contact email	dbecher@uni-greifswald.de
lab head
Thomas Sura
contact affiliation	Ernst-Moritz-Arndt-University Greifswald Institute for Microbiology Department of Microbial Proteomics
contact email	thomas.sura@uni-greifswald.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD009081

PRIDE project URI

• PRIDE
  1. PXD009081
     1. Label: PRIDE project
     2. Name: Oral Pathogen ‘Neutralizes’ the Human Innate Immune Defence