PXD009079

PXD009079 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Human mitochondrial cysteine desulfurase complex
Description	Cysteine desulfurase plays central role in mitochondrial iron-sulfur cluster biogenesis not only by providing sulfur through the catalysis of L-cysteine to L-alanine but also by serving as the platform for the assembly of other components of the biosynthetic machinery, including ISCU, frataxin, and ferredoxin. Human mitochondrial cysteine desulfurase complex consists of a homodimer with three components: NFS1, ISD11 and acyl carrier protein (ACP). In this study we used chemical crosslinking coupled with tandem mass spectrometry (XC-MS) to investigate the structures of cysteine desulfurase complexes.
HostingRepository	PRIDE
AnnounceDate	2018-07-11
AnnouncementXML	Submission_2018-07-11_07:17:15.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD009079
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Kai Cai
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Deamidated: 0.9840160012245178; Oxidation: 15.994915008544922; Carbamidomethyl: 57.02146530151367
Instrument	LTQ Orbitrap Elite

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-03-01 01:42:39	ID requested
⏵ 1	2018-07-11 07:17:16	announced

Publication List

Cai K, Frederick RO, Dashti H, Markley JL, Architectural Features of Human Mitochondrial Cysteine Desulfurase Complexes from Crosslinking Mass Spectrometry and Small-Angle X-Ray Scattering. Structure, 26(8):1127-1136.e4(2018) [pubmed]

Cai K, Frederick RO, Dashti H, Markley JL, Architectural Features of Human Mitochondrial Cysteine Desulfurase Complexes from Crosslinking Mass Spectrometry and Small-Angle X-Ray Scattering. Structure, 26(8):1127-1136.e4(2018) [pubmed]

Keyword List

curator keyword: Biological
submitter keyword: Human, cysteine desulfurase, CX-MS

curator keyword: Biological

submitter keyword: Human, cysteine desulfurase, CX-MS

Contact List

John L Markley
contact affiliation	Department of Biochemistry University of Wisconsin-Madison
contact email	markley@biochem.wisc.edu
lab head
Kai Cai
contact affiliation	University of Wisconsin-Madison
contact email	kcai@wisc.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/07/PXD009079
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/07/PXD009079

PRIDE project URI

Repository Record List

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