PXD009069

PXD009069 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Age-dependent changes in the sarkosyl-insoluble proteome of the APPswe/PS1de9 mouse model of Alzheimer's disease implicate dysfunctional mitochondria in disease pathogenesis
Description	This study was designed to identify and quantify pre-fibrillary proteins enriched by their insolubility in the detergent sarkosyl. Sarkosyl insoluble fractions were isolated from the brain of APP/PS1 transgenic mouse model of Alzheimer's disease and littermate wild type mice to identify protein aggregates involved in disease pathogenesis.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:04:05.289.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Camilla Thygesen
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iTRAQ4plex-116 reporter+balance reagent acylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-02-28 07:16:56	ID requested
1	2020-05-21 18:25:39	announced
⏵ 2	2024-10-22 05:04:05	announced	2024-10-22: Updated project metadata.

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

curator keyword: Biological, Biomedical
submitter keyword: Mouse, Alzheimer's disease, Orbitrap Fusion Lumos

curator keyword: Biological, Biomedical

submitter keyword: Mouse, Alzheimer's disease, Orbitrap Fusion Lumos

Contact List

Martin Røssel Larsen
contact affiliation	University of Southern Denmark, department of biochemistry and molecular biology, Protein research group, Denmark
contact email	mrl@bmb.sdu.dk
lab head
Camilla Thygesen
contact affiliation	University of Southern Denmark
contact email	cthygesen@health.sdu.dk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD009069
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD009069

PRIDE project URI

Repository Record List

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