PXD009056

PXD009056 is an original dataset announced via ProteomeXchange.

Title	Gut microbial functional maturation and succession during early life
Description	The evolutional trajectory of gut microbial colonization from birth has been shown to prime for health later in life. Here, we combined cultivation-independent 16S rRNA gene sequencing and metaproteomics to investigate the functional maturation of gut microbiota in faecal samples from full-term healthy infants collected at 6 and 18 months of age. Phylogenetic analysis of the metaproteomes showed that Bifidobacterium provided the highest number of distinct protein groups. Considerable divergences between taxa abundance and protein phylogeny were observed at all taxonomic ranks. Age had a profound effect on early microbiota where compositional and functional complexity of less dissimilar communities increased with time. Comparisons of the relative abundances of proteins revealed the transition of taxon-associated saccharolytic and carbon metabolism strategies from catabolic pathways of milk and mucin-derived monosaccharides feeding acetate/propanoate synthesis to complex food sugars fuelling butyrate production. Furthermore, co-occurrence network analysis uncovered two anti-correlated modules of functional taxa. A low-connected Bifidobacteriaceae-centred guild of facultative anaerobes was succeeded by a rich club of obligate anaerobes densely interconnected around Lachnospiraceae, underpinning their pivotal roles in microbial ecosystem assemblies. Our findings establish a framework to visualize whole microbial community metabolism and ecosystem succession dynamics, proposing opportunities for microbiota-targeted health-promoting strategies early in life.
HostingRepository	PRIDE
AnnounceDate	2018-07-16
AnnouncementXML	Submission_2018-07-16_02:18:08.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nico Jehmlich
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-02-27 07:36:25	ID requested
⏵ 1	2018-07-16 02:18:09	announced

Cerd, ó T, Ruiz A, Acu, ñ, a I, J, á, uregui R, Jehmlich N, Haange SB, von Bergen M, Su, á, rez A, Campoy C, Gut microbial functional maturation and succession during human early life. Environ Microbiol, 20(6):2160-2177(2018) [pubmed]

curator keyword: Biological

submitter keyword: Gut microbiome

infants

metaproteomics

early life

Martin von Bergen
contact affiliation	Prof. Dr. Martin von Bergen Helmholtz Centre for Environmental Research - UFZ Head of Department for Molecular Systems Biology http://www.ufz.de/index.php?de=17634 Professor of Functional Proteomics Faculty of Life Sciences, Pharmacy and Psychology University of Leipzig Permoserstr. 15 04318 Leipzig GERMANY
contact email	martin.vonbergen@ufz.de
lab head
Nico Jehmlich
contact affiliation	Helmholtz-Centre for Environmental Research - UFZ
contact email	nico.jehmlich@ufz.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/07/PXD009056

PRIDE project URI

• PRIDE
  1. PXD009056
     1. Label: PRIDE project
     2. Name: Gut microbial functional maturation and succession during early life