PXD009034

PXD009034 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Defective Mitochondrial Lipid Oxidation Results in the Pathological Accumulation of Fat After Rotator Cuff Tear
Description	Myosteatosis, also known as fatty infiltration, is the pathological accumulation of lipid that occurs in conjunction with atrophy and fibrosis following rotator cuff injury. Little is known about the mechanisms by which lipid accumulates in myosteatosis, but many studies have demonstrated the degree of lipid infiltration negatively correlates with muscle function and regeneration. Identifying how reduced mechanical loading activates molecular pathways that lead to myosteatosis could help to develop targeted therapies to improve functional outcomes after rotator cuff repair. Our objective was to use cutting compare muscle fiber contracility, proteomic, RNA sequencing and shotgun metabolomics along with bioinformatics to identify potential pathways and cellular processes that are dysregulated after rotator cuff teaar.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:02:01.213.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Brian McDonagh
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	N-ethylmaleimide derivatized cysteine; monohydroxylated residue; deamidated residue
Instrument	LTQ Orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2018-02-26 03:17:45	ID requested
1	2020-04-15 02:19:29	announced
⏵ 2	2024-10-22 05:02:09	announced	2024-10-22: Updated project metadata.

Publication List

Gumucio JP, Qasawa AH, Ferrara PJ, Malik AN, Funai K, McDonagh B, Mendias CL, Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis. FASEB J, 33(7):7863-7881(2019) [pubmed]
10.1096/fj.201802457RR;

Gumucio JP, Qasawa AH, Ferrara PJ, Malik AN, Funai K, McDonagh B, Mendias CL, Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis. FASEB J, 33(7):7863-7881(2019) [pubmed]

10.1096/fj.201802457RR;

Keyword List

curator keyword: Biomedical
submitter keyword: short chain fatty acids, lipidomics, mitochondrial dysfunction, rotator cuff injury,Skeletal muscle

curator keyword: Biomedical

submitter keyword: short chain fatty acids, lipidomics, mitochondrial dysfunction, rotator cuff injury,Skeletal muscle

Contact List

Brian McDonagh
contact affiliation	Physiology, NUI Galway
contact email	brian.mcdonagh@nuigalway.ie
lab head
Brian McDonagh
contact affiliation	NUI Galway
contact email	brian.mcdonagh@nuigalway.ie
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/04/PXD009034

PRIDE project URI

Repository Record List

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