PXD009034 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Defective Mitochondrial Lipid Oxidation Results in the Pathological Accumulation of Fat After Rotator Cuff Tear |
Description | Myosteatosis, also known as fatty infiltration, is the pathological accumulation of lipid that occurs in conjunction with atrophy and fibrosis following rotator cuff injury. Little is known about the mechanisms by which lipid accumulates in myosteatosis, but many studies have demonstrated the degree of lipid infiltration negatively correlates with muscle function and regeneration. Identifying how reduced mechanical loading activates molecular pathways that lead to myosteatosis could help to develop targeted therapies to improve functional outcomes after rotator cuff repair. Our objective was to use cutting compare muscle fiber contracility, proteomic, RNA sequencing and shotgun metabolomics along with bioinformatics to identify potential pathways and cellular processes that are dysregulated after rotator cuff teaar. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:02:01.213.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Brian McDonagh |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | N-ethylmaleimide derivatized cysteine; monohydroxylated residue; deamidated residue |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-02-26 03:17:45 | ID requested | |
1 | 2020-04-15 02:19:29 | announced | |
⏵ 2 | 2024-10-22 05:02:09 | announced | 2024-10-22: Updated project metadata. |
Publication List
Gumucio JP, Qasawa AH, Ferrara PJ, Malik AN, Funai K, McDonagh B, Mendias CL, Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis. FASEB J, 33(7):7863-7881(2019) [pubmed] |
10.1096/fj.201802457RR; |
Keyword List
curator keyword: Biomedical |
submitter keyword: short chain fatty acids, lipidomics, mitochondrial dysfunction, rotator cuff injury,Skeletal muscle |
Contact List
Brian McDonagh |
contact affiliation | Physiology, NUI Galway |
contact email | brian.mcdonagh@nuigalway.ie |
lab head | |
Brian McDonagh |
contact affiliation | NUI Galway |
contact email | brian.mcdonagh@nuigalway.ie |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/04/PXD009034 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD009034
- Label: PRIDE project
- Name: Defective Mitochondrial Lipid Oxidation Results in the Pathological Accumulation of Fat After Rotator Cuff Tear