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PXD009034

PXD009034 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDefective Mitochondrial Lipid Oxidation Results in the Pathological Accumulation of Fat After Rotator Cuff Tear
DescriptionMyosteatosis, also known as fatty infiltration, is the pathological accumulation of lipid that occurs in conjunction with atrophy and fibrosis following rotator cuff injury. Little is known about the mechanisms by which lipid accumulates in myosteatosis, but many studies have demonstrated the degree of lipid infiltration negatively correlates with muscle function and regeneration. Identifying how reduced mechanical loading activates molecular pathways that lead to myosteatosis could help to develop targeted therapies to improve functional outcomes after rotator cuff repair. Our objective was to use cutting compare muscle fiber contracility, proteomic, RNA sequencing and shotgun metabolomics along with bioinformatics to identify potential pathways and cellular processes that are dysregulated after rotator cuff teaar.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:02:01.213.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBrian McDonagh
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationListN-ethylmaleimide derivatized cysteine; monohydroxylated residue; deamidated residue
InstrumentLTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-02-26 03:17:45ID requested
12020-04-15 02:19:29announced
22024-10-22 05:02:09announced2024-10-22: Updated project metadata.
Publication List
Gumucio JP, Qasawa AH, Ferrara PJ, Malik AN, Funai K, McDonagh B, Mendias CL, Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis. FASEB J, 33(7):7863-7881(2019) [pubmed]
10.1096/fj.201802457RR;
Keyword List
curator keyword: Biomedical
submitter keyword: short chain fatty acids, lipidomics, mitochondrial dysfunction, rotator cuff injury,Skeletal muscle
Contact List
Brian McDonagh
contact affiliationPhysiology, NUI Galway
contact emailbrian.mcdonagh@nuigalway.ie
lab head
Brian McDonagh
contact affiliationNUI Galway
contact emailbrian.mcdonagh@nuigalway.ie
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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