This study contains multiple omic data sets. Here we have data from a quantitative metaproteomic, metabolomic, and serum proteomic analysis of 40 patients with varying severity of Ulcerative Colitis. Fecal samples were analyzed through proteomics using TMT MS3 quantitation. Fecal samples were analyzed for metabolomics through LCMS2 on a Bruker Maxis qTOF. Samples were selected based on clinical endoscopic scores.