PXD009025

PXD009025 is an original dataset announced via ProteomeXchange.

Title	Quantification of calcyclin and heat shock protein 90 in sera from women with and without preeclampsia by mass spectrometry
Description	Maternal serum levels of calcyclin and heat shock protein 90 were compared throughout pregnancy from the first trimester till term among women with preeclampsia (PE) and age-matched normotensive pregnant controls (C). Serum samples from two different studies, a nested case-control study embedded in the Rotterdam periconception cohort and the Lepra Study both conducted at the Erasmus MC in Rotterdam. They were collected in the first, second and third trimester of pregnancy in 43 patients with preeclampsia, consisting of 20 early-onset and 23 late-onset preeclampsia, and 46 normotensive pregnant controls. A serum based 2D LC-MS assay on Parallel Reaction Monitoring mode using a high resolution tribrid mass spectrometer was used to quantify both calcyclin and heat shock protein 90.
HostingRepository	PRIDE
AnnounceDate	2018-11-21
AnnouncementXML	Submission_2018-11-21_06:10:55.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Coskun Guzel
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2018-02-23 05:36:41	ID requested
⏵ 1	2018-11-21 06:10:56	announced

G, ü, zel C, van den Berg CB, Duvekot JJ, Stingl C, van den Bosch TPP, van der Weiden M, Steegers EAP, Steegers-Theunissen RPM, Luider TM, Quantification of Calcyclin and Heat Shock Protein 90 in Sera from Women with and without Preeclampsia by Mass Spectrometry. Proteomics Clin Appl, 13(3):e1800181(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: HSP90, placenta, preeclampsia, PRM, serum, S100A6

Theo Luider
contact affiliation	Head of Laboratory of Neuro-Oncology Clinical & Cancer Proteomics the Netherlands
contact email	t.luider@erasmusmc.nl
lab head
Coskun Guzel
contact affiliation	Erasmus MC
contact email	c.guzel@erasmusmc.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/11/PXD009025

PRIDE project URI

• PRIDE
  1. PXD009025
     1. Label: PRIDE project
     2. Name: Quantification of calcyclin and heat shock protein 90 in sera from women with and without preeclampsia by mass spectrometry