PXD009005

PXD009005 is an original dataset announced via ProteomeXchange.

Title	Mouse spleen LC-MSMS: effects of age and immune challenge
Description	Ageing is characterized by the progressive lowering of the acute innate immune response and the progressive up-regulation of low-grade inflammation (i.e. inflammaging). At the cellular level, telomeres are considered as a mark of ageing as their length is progressively shortened. However, the links between telomeres and innate immune ageing remain undefined. Using a proteomic approach conducted on laboratory mice, we tested whether the experimental triggering of an acute innate response is deleterious for telomere maintenance, and whether this is dependent of age. To do so, we challenged young and old mice using bacterial lipopolysaccharide (LPS) and measured individuals’ end-points of telomere length and proteomic profiles in spleen tissue.
HostingRepository	PRIDE
AnnounceDate	2019-03-12
AnnouncementXML	Submission_2019-03-12_04:25:29.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fabrice BERTILE
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	impact HD

Revision	Datetime	Status	ChangeLog Entry
0	2018-02-21 07:27:58	ID requested
⏵ 1	2019-03-12 04:25:31	announced

Criscuolo F, Sorci G, Behaim-Delarbre M, Zahn S, Faivre B, Bertile F, Age-related response to an acute innate immune challenge in mice: proteomics reveals a telomere maintenance-related cost. Proc Biol Sci, 285(1892):(2018) [pubmed]

curator keyword: Biological

submitter keyword: Mouse, spleen, LPS, ageing, LC-MSMS

Sarah Cianférani
contact affiliation	Laboratoire de Spectrométrie de Masse BioOrganique, Analytical Science department, IPHC, CNRS, Strasbourg University, UMR7178, Strasbourg, France
contact email	sarah.cianferani@unistra.fr
lab head
Fabrice BERTILE
contact affiliation	CNRS
contact email	fbertile@unistra.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD009005

PRIDE project URI

• PRIDE
  1. PXD009005
     1. Label: PRIDE project
     2. Name: Mouse spleen LC-MSMS: effects of age and immune challenge